Mouse models of uterine corpus tumors: Clinical significance and utility

Anne M. Friel, Whitfield B. Growdon, Christopher K. McCann, Alexander B. Olawaiye, Elizabeth G. Munro, John O. Schorge, Diego H. Castrillon, Russell R. Broaddus, Bo R. Rueda

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Uterine tumors, whether benign or malignant, are diagnosed in a significant portion of women and are associated with a number of co-morbidities that negatively impact quality of life. Uterine tumors can be derived from the epithelial (endometrial hyperplasia or carcinoma) and mesenchymal (leiomyoma, sarcoma) layers of the uterus. The exact etiologies of the various tumor types are yet to be defined. Collectively their development and progression often results from aberrant steroid hormone exposure or dysregulation of related growth factor signaling and apoptotic pathways, reflecting the role of steroid hormone-dependent signaling and survival pathways in the cycles of cell growth and involution that characterize normal uterine physiology. While molecular analyses of human tumors can identify candidate genetic and epigenetic lesions contributing to uterine tumor initiation and progression, in vivo genetic models are needed to establish the functional significance of such lesions and their contribution to tumorigenesis. For this purpose, genetically-engineered mouse models have proven valuable. Here we review genetically-modified mouse models that develop uterine tumors and compare their pathology, utility/feasibility, and discuss their clinical relevance.

Original languageEnglish (US)
Pages (from-to)882-895
Number of pages14
JournalFrontiers in Bioscience - Elite
Volume2 E
Issue number3
StatePublished - Jun 1 2010

Fingerprint

Tumors
Steroid hormones
Neoplasms
Steroids
Hormones
Endometrial Hyperplasia
Genetic Models
Physiology
Leiomyoma
Cell growth
Pathology
Endometrial Neoplasms
Epigenomics
Sarcoma
Uterus
Intercellular Signaling Peptides and Proteins
Cell Cycle
Carcinogenesis
Quality of Life
Morbidity

Keywords

  • Cancer
  • Endometrium
  • Hyperplasis
  • Leiomyoma
  • Mouse models
  • Review
  • Uterus

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Friel, A. M., Growdon, W. B., McCann, C. K., Olawaiye, A. B., Munro, E. G., Schorge, J. O., ... Rueda, B. R. (2010). Mouse models of uterine corpus tumors: Clinical significance and utility. Frontiers in Bioscience - Elite, 2 E(3), 882-895.

Mouse models of uterine corpus tumors : Clinical significance and utility. / Friel, Anne M.; Growdon, Whitfield B.; McCann, Christopher K.; Olawaiye, Alexander B.; Munro, Elizabeth G.; Schorge, John O.; Castrillon, Diego H.; Broaddus, Russell R.; Rueda, Bo R.

In: Frontiers in Bioscience - Elite, Vol. 2 E, No. 3, 01.06.2010, p. 882-895.

Research output: Contribution to journalArticle

Friel, AM, Growdon, WB, McCann, CK, Olawaiye, AB, Munro, EG, Schorge, JO, Castrillon, DH, Broaddus, RR & Rueda, BR 2010, 'Mouse models of uterine corpus tumors: Clinical significance and utility', Frontiers in Bioscience - Elite, vol. 2 E, no. 3, pp. 882-895.
Friel AM, Growdon WB, McCann CK, Olawaiye AB, Munro EG, Schorge JO et al. Mouse models of uterine corpus tumors: Clinical significance and utility. Frontiers in Bioscience - Elite. 2010 Jun 1;2 E(3):882-895.
Friel, Anne M. ; Growdon, Whitfield B. ; McCann, Christopher K. ; Olawaiye, Alexander B. ; Munro, Elizabeth G. ; Schorge, John O. ; Castrillon, Diego H. ; Broaddus, Russell R. ; Rueda, Bo R. / Mouse models of uterine corpus tumors : Clinical significance and utility. In: Frontiers in Bioscience - Elite. 2010 ; Vol. 2 E, No. 3. pp. 882-895.
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