Mouse strain related differences in the biologic and immunologic responses to a murine sarcoma virus

A. F. Gazdar, E. K. Russell, R. B. Herberman

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Abstract

Important differences were present in the biologic and immunologic responses of 4 week old BALB/c, C3H, and (NZW x NZB)F1 (B/W) mice to a murine sarcoma virus (Gz MSV) isolated from a B/W mouse. Although the 3 strains rapidly developed large soft tissue tumors at the virus inoculation site, the tumors regressed in C3H mice but grew progressively in BALB/c mice. These 2 strains showed excellent correlation among tumor regression, virus titers, and plasma levels of virus neutralizing and cytotoxic antibodies. The biologic responses of B/W mice to the virus were complex and were not correlated with the humoral immune responses. Tumors in B/W mice persisted for long periods, despite histologic evidence of rejection and high levels of cytotoxic antibodies. Cellular immune responses to the tumor were relatively weak in all 3 strains. B/W mice developed massive splenomegaly, with extensive inflammatory fibrosis and vascular proliferation replacing the normal architecture. The biologic responses of NZB and B/W mice to Gz MSV were similar. Splenectomy did not prevent the death of virus inoculated BALB/c, NZB, and B/W mice but it prolonged the survival time of B/W mice.

Original languageEnglish (US)
Pages (from-to)971-978
Number of pages8
JournalJournal of the National Cancer Institute
Volume50
Issue number4
StatePublished - 1973

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Murine Sarcoma Viruses
Oncogenic Viruses
Viruses
Neoplasms
Inbred C3H Mouse
Splenomegaly
Splenectomy
Humoral Immunity
Neutralizing Antibodies
Viral Load
Cellular Immunity
Blood Vessels
Fibrosis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Mouse strain related differences in the biologic and immunologic responses to a murine sarcoma virus. / Gazdar, A. F.; Russell, E. K.; Herberman, R. B.

In: Journal of the National Cancer Institute, Vol. 50, No. 4, 1973, p. 971-978.

Research output: Contribution to journalArticle

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