Moxalactam for treatment of pelvic infections after cesarean delivery.

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Abstract

Moxalactam was given to 136 women for treatment of uterine infections after cesarean delivery. After an intravenous loading dose of 2 g, 36 women received 3 g daily and 100 were given 6 g daily. The clinical success rates of these two regimens were 86% and 89%, respectively; however, in four of five women for whom treatment with the 3-g daily dose failed, extensive surgery was necessary for cure. A total of 395 pathogens was isolated from these women with polymicrobial infections, and almost 90% were susceptible to moxalactam at less than or equal to 32 micrograms/ml. Adverse effects of therapy were minimal. Thus, moxalactam given initially as a dosage of 6 g daily is effective for treatment of women with pelvic infections after cesarean delivery.

Original languageEnglish (US)
JournalReviews of Infectious Diseases
Volume4 Suppl
StatePublished - Nov 1982

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Pelvic Infection
Moxalactam
Therapeutics
Coinfection
Infection

ASJC Scopus subject areas

  • Microbiology (medical)

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Moxalactam for treatment of pelvic infections after cesarean delivery. / Cunningham, F. G.; Gibbs, R. S.; Hemsell, D. L.

In: Reviews of Infectious Diseases, Vol. 4 Suppl, 11.1982.

Research output: Contribution to journalArticle

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abstract = "Moxalactam was given to 136 women for treatment of uterine infections after cesarean delivery. After an intravenous loading dose of 2 g, 36 women received 3 g daily and 100 were given 6 g daily. The clinical success rates of these two regimens were 86{\%} and 89{\%}, respectively; however, in four of five women for whom treatment with the 3-g daily dose failed, extensive surgery was necessary for cure. A total of 395 pathogens was isolated from these women with polymicrobial infections, and almost 90{\%} were susceptible to moxalactam at less than or equal to 32 micrograms/ml. Adverse effects of therapy were minimal. Thus, moxalactam given initially as a dosage of 6 g daily is effective for treatment of women with pelvic infections after cesarean delivery.",
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