Moxalactam versus cefazolin prophylaxis for vaginal hysterectomy

Moxalactam is a newer β-lactam antibiotic with increased activity and an extended antimicrobial spectrum. Three 1 gm doses were given to women scheduled for elective vaginal hysterectomy. This perioperative regimen was prospectively compared to identical doses of cefazolin, a first-generation cephalosporin of proved efficacy. The overall incidence of major postoperative infection in 193 women was <5% and there were no significant interregimen differences. The incidence of major infection was directly related to the type of procedure performed.