MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation

Catherine A. Makarewich, Kedryn K. Baskin, Amir Z. Munir, Svetlana Bezprozvannaya, Gaurav Sharma, Chalermchai Khemtong, Akansha M. Shah, John R. McAnally, Craig R. Malloy, Luke I. Szweda, Rhonda Bassel-Duby, Eric N. Olson

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Micropeptide regulator of β-oxidation (MOXI) is encoded by a muscle-enriched RNA transcript misannotated as non-coding. MOXI localizes to the inner mitochondrial membrane where it interacts with the trifunctional protein to modulate fatty acid β-oxidation and exercise capacity.

Original languageEnglish (US)
Pages (from-to)3701-3709
Number of pages9
JournalCell Reports
Volume23
Issue number13
DOIs
StatePublished - Jun 26 2018

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Mitochondrial Membranes
Fatty Acids
RNA
Muscles
Oxidation
Proteins
Muscle
Membranes

Keywords

  • fatty acid oxidation
  • metabolism
  • micropeptide
  • mitochondria
  • noncoding RNA
  • trifunctional protein

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Makarewich, C. A., Baskin, K. K., Munir, A. Z., Bezprozvannaya, S., Sharma, G., Khemtong, C., ... Olson, E. N. (2018). MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation. Cell Reports, 23(13), 3701-3709. https://doi.org/10.1016/j.celrep.2018.05.058

MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation. / Makarewich, Catherine A.; Baskin, Kedryn K.; Munir, Amir Z.; Bezprozvannaya, Svetlana; Sharma, Gaurav; Khemtong, Chalermchai; Shah, Akansha M.; McAnally, John R.; Malloy, Craig R.; Szweda, Luke I.; Bassel-Duby, Rhonda; Olson, Eric N.

In: Cell Reports, Vol. 23, No. 13, 26.06.2018, p. 3701-3709.

Research output: Contribution to journalArticle

Makarewich, CA, Baskin, KK, Munir, AZ, Bezprozvannaya, S, Sharma, G, Khemtong, C, Shah, AM, McAnally, JR, Malloy, CR, Szweda, LI, Bassel-Duby, R & Olson, EN 2018, 'MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation', Cell Reports, vol. 23, no. 13, pp. 3701-3709. https://doi.org/10.1016/j.celrep.2018.05.058
Makarewich CA, Baskin KK, Munir AZ, Bezprozvannaya S, Sharma G, Khemtong C et al. MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation. Cell Reports. 2018 Jun 26;23(13):3701-3709. https://doi.org/10.1016/j.celrep.2018.05.058
Makarewich, Catherine A. ; Baskin, Kedryn K. ; Munir, Amir Z. ; Bezprozvannaya, Svetlana ; Sharma, Gaurav ; Khemtong, Chalermchai ; Shah, Akansha M. ; McAnally, John R. ; Malloy, Craig R. ; Szweda, Luke I. ; Bassel-Duby, Rhonda ; Olson, Eric N. / MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation. In: Cell Reports. 2018 ; Vol. 23, No. 13. pp. 3701-3709.
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