MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation

Catherine A. Makarewich, Kedryn K. Baskin, Amir Z. Munir, Svetlana Bezprozvannaya, Gaurav Sharma, Chalermchai Khemtong, Akansha M. Shah, John R. McAnally, Craig R. Malloy, Luke I. Szweda, Rhonda Bassel-Duby, Eric N. Olson

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Micropeptide regulator of β-oxidation (MOXI) is encoded by a muscle-enriched RNA transcript misannotated as non-coding. MOXI localizes to the inner mitochondrial membrane where it interacts with the trifunctional protein to modulate fatty acid β-oxidation and exercise capacity.

Original languageEnglish (US)
Pages (from-to)3701-3709
Number of pages9
JournalCell Reports
Volume23
Issue number13
DOIs
StatePublished - Jun 26 2018

Keywords

  • fatty acid oxidation
  • metabolism
  • micropeptide
  • mitochondria
  • noncoding RNA
  • trifunctional protein

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Makarewich, C. A., Baskin, K. K., Munir, A. Z., Bezprozvannaya, S., Sharma, G., Khemtong, C., Shah, A. M., McAnally, J. R., Malloy, C. R., Szweda, L. I., Bassel-Duby, R., & Olson, E. N. (2018). MOXI Is a Mitochondrial Micropeptide That Enhances Fatty Acid β-Oxidation. Cell Reports, 23(13), 3701-3709. https://doi.org/10.1016/j.celrep.2018.05.058