MPTP is proconvulsant acutely but has no long-term effect in rodent models of seizure and epilepsy

Paul C. Van Ness, Richard W. Olsen, M. Anthony Verity

Research output: Contribution to journalArticle

12 Scopus citations


1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) was used to lesion the substantia nigra of rodents to look for changes in various animal models of epilepsy and seizures. MPTP, acutely administered to C57BL/6J mice, could cause seizures at high doses and enhanced maximal electroshock seizures at lower doses. Older mice were more sensitive to MPTP toxicity. MPTP given over 1 week to produce a 75% drop of striatal dopamine had no effect on seizure thresholds to pentylenetetrazol or picrotoxin and did not change the maximal electroshock seizure. Epileptic gerbils given maximally tolerated doses of MPTP had only a slight striatal dopamine reduction (32%) while seizures remained unaltered. The data are consistent with the hypothesis that chronic dysfunction of dopamine containing substantia nigra neurons have no significant influence on seizures in these animal models.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalBrain Research
Issue number2
StatePublished - Dec 18 1989



  • 1-Methyl-4-phenyl-1,2,5,6,-tetrahydropyridine
  • Epilepsy
  • Mongolian gerbil
  • Mouse
  • Seizure
  • Substantia nigra

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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