MPTP is proconvulsant acutely but has no long-term effect in rodent models of seizure and epilepsy

Paul C. Van Ness, Richard W. Olsen, M. Anthony Verity

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP) was used to lesion the substantia nigra of rodents to look for changes in various animal models of epilepsy and seizures. MPTP, acutely administered to C57BL/6J mice, could cause seizures at high doses and enhanced maximal electroshock seizures at lower doses. Older mice were more sensitive to MPTP toxicity. MPTP given over 1 week to produce a 75% drop of striatal dopamine had no effect on seizure thresholds to pentylenetetrazol or picrotoxin and did not change the maximal electroshock seizure. Epileptic gerbils given maximally tolerated doses of MPTP had only a slight striatal dopamine reduction (32%) while seizures remained unaltered. The data are consistent with the hypothesis that chronic dysfunction of dopamine containing substantia nigra neurons have no significant influence on seizures in these animal models.

Original languageEnglish (US)
Pages (from-to)289-292
Number of pages4
JournalBrain Research
Volume504
Issue number2
DOIs
StatePublished - Dec 18 1989

Fingerprint

Rodentia
Epilepsy
Seizures
Corpus Striatum
Dopamine
Electroshock
Substantia Nigra
Animal Models
Picrotoxin
Pentylenetetrazole
Maximum Tolerated Dose
Gerbillinae
Inbred C57BL Mouse
Neurons

Keywords

  • 1-Methyl-4-phenyl-1,2,5,6,-tetrahydropyridine
  • Epilepsy
  • Mongolian gerbil
  • Mouse
  • Seizure
  • Substantia nigra

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

MPTP is proconvulsant acutely but has no long-term effect in rodent models of seizure and epilepsy. / Van Ness, Paul C.; Olsen, Richard W.; Verity, M. Anthony.

In: Brain Research, Vol. 504, No. 2, 18.12.1989, p. 289-292.

Research output: Contribution to journalArticle

Van Ness, Paul C. ; Olsen, Richard W. ; Verity, M. Anthony. / MPTP is proconvulsant acutely but has no long-term effect in rodent models of seizure and epilepsy. In: Brain Research. 1989 ; Vol. 504, No. 2. pp. 289-292.
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