MR classification of renal masses with pathologic correlation

Ivan Pedrosa, Mary T. Chou, Long Ngo, Ronaldo H. Baroni, Elizabeth M. Genega, Laura Galaburda, William C. DeWolf, Neil M. Rofsky

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

To perform a feature analysis of malignant renal tumors evaluated with magnetic resonance (MR) imaging and to investigate the correlation between MR imaging features and histopathological findings. MR examinations in 79 malignant renal masses were retrospectively evaluated, and a feature analysis was performed. Each renal mass was assigned to one of eight categories from a proposed MRI classification system. The sensitivity and specificity of the MRI classification system to predict the histologic subtype and nuclear grade was calculated. Subvoxel fat on chemical shift imaging correlated to clear cell type (p < 0.05); sensitivity = 42%, specificity = 100%. Large size, intratumoral necrosis, retroperitoneal vascular collaterals, and renal vein thrombosis predicted high-grade clear cell type (p < 0.05). Small size, peripheral location, low intratumoral SI on T2-weighted images, and low-level enhancement were associated with low-grade papillary carcinomas (p < 0.05). The sensitivity and specificity of the MRI classification system for diagnosing low grade clear cell, high-grade clear cell, all clear cell, all papillary, and transitional carcinomas were 50% and 94%, 93% and 75%, 92% and 83%, 80% and 94%, and 100% and 99%, respectively. The MRI feature analysis and proposed classification system help predict the histological type and nuclear grade of renal masses.

Original languageEnglish (US)
Pages (from-to)365-375
Number of pages11
JournalEuropean Radiology
Volume18
Issue number2
DOIs
StatePublished - Feb 2008

Fingerprint

Magnetic Resonance Spectroscopy
Kidney
Papillary Carcinoma
Magnetic Resonance Imaging
Sensitivity and Specificity
Naphazoline
Renal Veins
Blood Vessels
Thrombosis
Necrosis
Fats
Neoplasms

Keywords

  • Carcinoma
  • Kidney neoplasms
  • Magnetic resonance imaging
  • Multivariate analysis
  • Renal cell

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

MR classification of renal masses with pathologic correlation. / Pedrosa, Ivan; Chou, Mary T.; Ngo, Long; Baroni, Ronaldo H.; Genega, Elizabeth M.; Galaburda, Laura; DeWolf, William C.; Rofsky, Neil M.

In: European Radiology, Vol. 18, No. 2, 02.2008, p. 365-375.

Research output: Contribution to journalArticle

Pedrosa, I, Chou, MT, Ngo, L, Baroni, RH, Genega, EM, Galaburda, L, DeWolf, WC & Rofsky, NM 2008, 'MR classification of renal masses with pathologic correlation', European Radiology, vol. 18, no. 2, pp. 365-375. https://doi.org/10.1007/s00330-007-0757-0
Pedrosa I, Chou MT, Ngo L, Baroni RH, Genega EM, Galaburda L et al. MR classification of renal masses with pathologic correlation. European Radiology. 2008 Feb;18(2):365-375. https://doi.org/10.1007/s00330-007-0757-0
Pedrosa, Ivan ; Chou, Mary T. ; Ngo, Long ; Baroni, Ronaldo H. ; Genega, Elizabeth M. ; Galaburda, Laura ; DeWolf, William C. ; Rofsky, Neil M. / MR classification of renal masses with pathologic correlation. In: European Radiology. 2008 ; Vol. 18, No. 2. pp. 365-375.
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