MR imaging in the management before surgery of lobular carcinoma of the breast: Correlation with pathology

G. N. Rodenko, S. E. Harms, J. M. Pruneda, R. S. Farrell, W. P. Evans, D. S. Copit, P. A. Krakos, D. P. Flamig

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Abstract

OBJECTIVE. Our objective was to investigate the use of MR imaging in preoperative staging and characterization of lobular carcinoma. MATERIALS AND METHODS. MR imaging studies and mammographic studies in 20 patients with infiltrating lobular carcinoma were evaluated and correlated with pathology findings on serially sectioned tissue. The MR images and mammograms were reviewed retrospectively by three independent examiners unaware of the clinical, imaging, and pathology findings. RESULTS. The extent of disease found pathologically correlated with that predicted by MR imaging studies in 85% of patients, compared with a 32% correlation (p < .0001) with mammographic studies. Interobserver agreement on lesion morphology and extent of disease was higher for MR imaging (91% and 100%, respectively) than for mammography (64% and 91%, respectively). The retrospective MR readings did not differ from the prospective reports. No false-positive lymphadenopathy was interpreted on MR imaging. Lymph nodes having metastatic lobular carcinoma on the pathology examination were missed on MR imaging in four patients. CONCLUSION. MR imaging is significantly more accurate than mammography in determining the extent of disease and characterizing the morphology of infiltrating lobular carcinoma. MR imaging may play a role in preoperative planning, especially when breast conservation is being considered.

Original languageEnglish (US)
Pages (from-to)1415-1419
Number of pages5
JournalAmerican Journal of Roentgenology
Volume167
Issue number6
StatePublished - 1996

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Lobular Carcinoma
Breast
Pathology
Mammography
Clinical Pathology
Reading
Lymph Nodes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Rodenko, G. N., Harms, S. E., Pruneda, J. M., Farrell, R. S., Evans, W. P., Copit, D. S., ... Flamig, D. P. (1996). MR imaging in the management before surgery of lobular carcinoma of the breast: Correlation with pathology. American Journal of Roentgenology, 167(6), 1415-1419.

MR imaging in the management before surgery of lobular carcinoma of the breast : Correlation with pathology. / Rodenko, G. N.; Harms, S. E.; Pruneda, J. M.; Farrell, R. S.; Evans, W. P.; Copit, D. S.; Krakos, P. A.; Flamig, D. P.

In: American Journal of Roentgenology, Vol. 167, No. 6, 1996, p. 1415-1419.

Research output: Contribution to journalArticle

Rodenko, GN, Harms, SE, Pruneda, JM, Farrell, RS, Evans, WP, Copit, DS, Krakos, PA & Flamig, DP 1996, 'MR imaging in the management before surgery of lobular carcinoma of the breast: Correlation with pathology', American Journal of Roentgenology, vol. 167, no. 6, pp. 1415-1419.
Rodenko, G. N. ; Harms, S. E. ; Pruneda, J. M. ; Farrell, R. S. ; Evans, W. P. ; Copit, D. S. ; Krakos, P. A. ; Flamig, D. P. / MR imaging in the management before surgery of lobular carcinoma of the breast : Correlation with pathology. In: American Journal of Roentgenology. 1996 ; Vol. 167, No. 6. pp. 1415-1419.
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N2 - OBJECTIVE. Our objective was to investigate the use of MR imaging in preoperative staging and characterization of lobular carcinoma. MATERIALS AND METHODS. MR imaging studies and mammographic studies in 20 patients with infiltrating lobular carcinoma were evaluated and correlated with pathology findings on serially sectioned tissue. The MR images and mammograms were reviewed retrospectively by three independent examiners unaware of the clinical, imaging, and pathology findings. RESULTS. The extent of disease found pathologically correlated with that predicted by MR imaging studies in 85% of patients, compared with a 32% correlation (p < .0001) with mammographic studies. Interobserver agreement on lesion morphology and extent of disease was higher for MR imaging (91% and 100%, respectively) than for mammography (64% and 91%, respectively). The retrospective MR readings did not differ from the prospective reports. No false-positive lymphadenopathy was interpreted on MR imaging. Lymph nodes having metastatic lobular carcinoma on the pathology examination were missed on MR imaging in four patients. CONCLUSION. MR imaging is significantly more accurate than mammography in determining the extent of disease and characterizing the morphology of infiltrating lobular carcinoma. MR imaging may play a role in preoperative planning, especially when breast conservation is being considered.

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