MR microscopy of the lung in small rodents

Masaya Takahashi, Shigeto Kubo, Shigeru Kiryu, James Gee, Hiroto Hatabu

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Understanding how the mammalian respiratory system works and how it changes in disease states and under the influence of drugs is frequently pursued in model systems such as small rodents. These have many advantages, including being easily obtained in large numbers as purebred strains. Studies in small rodents are valuable for proof of concept studies and for increasing our knowledge about disease mechanisms. Since the recent developments in the generation of genetically designed animal models of disease, one needs the ability to assess morphology and function in in vivo systems. In this article, we first review previous reports regarding thoracic imaging. We then discuss approaches to take in making use of small rodents to increase MR microscopic sensitivity for these studies and to establish MR methods for clinically relevant lung imaging.

Original languageEnglish (US)
Pages (from-to)367-374
Number of pages8
JournalEuropean Journal of Radiology
Volume64
Issue number3
DOIs
StatePublished - Dec 1 2007

Keywords

  • Lung cancer
  • MR microscopy
  • Mice
  • Perfusion-ventilation
  • Respiratory motion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Takahashi, M., Kubo, S., Kiryu, S., Gee, J., & Hatabu, H. (2007). MR microscopy of the lung in small rodents. European Journal of Radiology, 64(3), 367-374. https://doi.org/10.1016/j.ejrad.2007.08.011