MR neurographic orthopantomogram

Ultrashort echo-time imaging of mandibular bone and teeth complemented with high-resolution morphological and functional MR neurography

Andrei Manoliu, Michael Ho, Daniel Nanz, Evelyn Dappa, Andreas Boss, David M. Grodzki, Wei Liu, Avneesh Chhabra, Gustav Andreisek, Felix P. Kuhn

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: Panoramical radiographs or cone-beam computed tomography (CT) are the standard-of-care in dental imaging to assess teeth, mandible, and mandibular canal pathologies, but do not allow assessment of the inferior alveolar nerve itself nor of its branches. We propose a new technique for “MR neurographic orthopantomograms” exploiting ultrashort echo-time (UTE) imaging of bone and teeth complemented with high-resolution morphological and functional MR neurography. Materials and Methods: The Institutional Review Board approved the study in 10 healthy volunteers. Imaging of the subjects mandibles at 3.0T (Magnetom Skyra, Siemens-Healthcare) using a 64-channel head coil with isotropic spatial resolution for subsequent multiplanar reformatting, was performed. Bone images were acquired using a 3D PETRA sequence (TE, 0.07 msec). Morphological nerve imaging was performed using a dedicated 3D PSIF and 3D SPACE STIR sequence. Functional MR neurography was accomplished using a new accelerated diffusion-tensor-imaging (DTI) prototype sequence (2D SMS-accelerated RESOLVE). Qualitative and quantitative image analysis was performed and descriptive statistics are provided. Results: Image acquisition and subsequent postprocessing into the MR neurographic orthopantomogram by overlay of morphological and functional images were feasible in all 10 volunteers without artifacts. All mandibular bones and mandibular nerves were assessable and considered normal. Fiber tractography with quantitative evaluation of physiological diffusion properties of mandibular nerves yielded the following mean ± SD values: fractional anisotropy, 0.43 ± 0.07; mean diffusivity (mm2/s), 0.0014 ± 0.0002; axial diffusivity, 0.0020 ± 0.0002, and radial diffusivity, 0.0011 ± 0.0001. Conclusion: The proposed technique of MR neurographic orthopantomogram exploiting UTE imaging complemented with high-resolution morphological and functional MR neurography was feasible and allowed comprehensive assessment of osseous texture and neural microarchitecture in a single examination. J. Magn. Reson. Imaging 2016;44:393–400.

Original languageEnglish (US)
Pages (from-to)393-400
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume44
Issue number2
DOIs
StatePublished - Aug 1 2016

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Mandibular Nerve
Tooth
Mandible
Bone and Bones
Diffusion Tensor Imaging
Cone-Beam Computed Tomography
Research Ethics Committees
Anisotropy
Standard of Care
Artifacts
Volunteers
Healthy Volunteers
Head
Pathology
Delivery of Health Care

Keywords

  • bone imaging
  • DTI peripheral nerves
  • maxillofacial imaging
  • MR neurography
  • PETRA
  • UTE

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

MR neurographic orthopantomogram : Ultrashort echo-time imaging of mandibular bone and teeth complemented with high-resolution morphological and functional MR neurography. / Manoliu, Andrei; Ho, Michael; Nanz, Daniel; Dappa, Evelyn; Boss, Andreas; Grodzki, David M.; Liu, Wei; Chhabra, Avneesh; Andreisek, Gustav; Kuhn, Felix P.

In: Journal of Magnetic Resonance Imaging, Vol. 44, No. 2, 01.08.2016, p. 393-400.

Research output: Contribution to journalArticle

Manoliu, Andrei ; Ho, Michael ; Nanz, Daniel ; Dappa, Evelyn ; Boss, Andreas ; Grodzki, David M. ; Liu, Wei ; Chhabra, Avneesh ; Andreisek, Gustav ; Kuhn, Felix P. / MR neurographic orthopantomogram : Ultrashort echo-time imaging of mandibular bone and teeth complemented with high-resolution morphological and functional MR neurography. In: Journal of Magnetic Resonance Imaging. 2016 ; Vol. 44, No. 2. pp. 393-400.
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abstract = "Purpose: Panoramical radiographs or cone-beam computed tomography (CT) are the standard-of-care in dental imaging to assess teeth, mandible, and mandibular canal pathologies, but do not allow assessment of the inferior alveolar nerve itself nor of its branches. We propose a new technique for “MR neurographic orthopantomograms” exploiting ultrashort echo-time (UTE) imaging of bone and teeth complemented with high-resolution morphological and functional MR neurography. Materials and Methods: The Institutional Review Board approved the study in 10 healthy volunteers. Imaging of the subjects mandibles at 3.0T (Magnetom Skyra, Siemens-Healthcare) using a 64-channel head coil with isotropic spatial resolution for subsequent multiplanar reformatting, was performed. Bone images were acquired using a 3D PETRA sequence (TE, 0.07 msec). Morphological nerve imaging was performed using a dedicated 3D PSIF and 3D SPACE STIR sequence. Functional MR neurography was accomplished using a new accelerated diffusion-tensor-imaging (DTI) prototype sequence (2D SMS-accelerated RESOLVE). Qualitative and quantitative image analysis was performed and descriptive statistics are provided. Results: Image acquisition and subsequent postprocessing into the MR neurographic orthopantomogram by overlay of morphological and functional images were feasible in all 10 volunteers without artifacts. All mandibular bones and mandibular nerves were assessable and considered normal. Fiber tractography with quantitative evaluation of physiological diffusion properties of mandibular nerves yielded the following mean ± SD values: fractional anisotropy, 0.43 ± 0.07; mean diffusivity (mm2/s), 0.0014 ± 0.0002; axial diffusivity, 0.0020 ± 0.0002, and radial diffusivity, 0.0011 ± 0.0001. Conclusion: The proposed technique of MR neurographic orthopantomogram exploiting UTE imaging complemented with high-resolution morphological and functional MR neurography was feasible and allowed comprehensive assessment of osseous texture and neural microarchitecture in a single examination. J. Magn. Reson. Imaging 2016;44:393–400.",
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AU - Dappa, Evelyn

AU - Boss, Andreas

AU - Grodzki, David M.

AU - Liu, Wei

AU - Chhabra, Avneesh

AU - Andreisek, Gustav

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