MRI-controlled rapidly scanned focused ultrasound hyperthermia for temperature sensitive localized drug delivery

Robert Staruch, Jeff Wachsmuth, Rajiv Chopra, Kullervo Hynynena

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Temperature sensitive drug delivery systems have been limited by a lack of versatile, noninvasive methods for applying uniform non-ablative heating. The objective of this study was to characterize and demonstrate an MRI-controlled scanned focused ultrasound system capable of maintaining temporally and spatially uniform target temperatures ex vivo. Degassed turkey breast was heated in a clinical 3T MRI using a single-element focused transducer rapidly scanned along a circular trajectory by an MRI-compatible transducer positioning system. Spatial temperature distribution was measured every 5s using the proton resonance frequency shift. Temperature at the center of the scan trajectory was used as input for proportional-integral control of applied acoustic power. Uniform temperature elevation of 10°C was maintained for several minutes in a 5 mm target diameter using controller gain values identified by numerical simulations. Simultaneous scanning and imaging caused a correctable periodic drift in baseline phase. Temporally and spatially uniform MRI-controlled scanned focused ultrasound hyperthermia was demonstrated ex vivo with a simple feedback control system.

Original languageEnglish (US)
Title of host publicationAIP Conference Proceedings
Pages438-442
Number of pages5
Volume1113
DOIs
Publication statusPublished - 2009
Event8th International Symposium on Therapeutic Ultrasound - Minneapolis, MN, United States
Duration: Sep 10 2008Sep 13 2008

Other

Other8th International Symposium on Therapeutic Ultrasound
CountryUnited States
CityMinneapolis, MN
Period9/10/089/13/08

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Keywords

  • Control
  • Drug delivery
  • Focused ultrasound
  • Hyperthermia
  • MRI
  • Thermometry

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Staruch, R., Wachsmuth, J., Chopra, R., & Hynynena, K. (2009). MRI-controlled rapidly scanned focused ultrasound hyperthermia for temperature sensitive localized drug delivery. In AIP Conference Proceedings (Vol. 1113, pp. 438-442) https://doi.org/10.1063/1.3131466