MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo

Elena Vinogradov, Huamei He, Angelo Lubag, James A. Baischi, A. Dean Sherry, Robert E. Lenkinski

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

In this report, the On resonance PARamagnetic CHemical Exchange Effects (OPARACHEE) method was implemented in vivo using WALTZ-16* as a preparation pulse with a standard spin echo sequence to detect the accumulation and clearance of the TmDOTA-4AmC- in mouse kidney. The performance of the technique in vivo is described in terms of the magnitude of the contrast effect versus the bolus agent concentration and signal-to-noise ratio (SNR) levels. The lowest injected concentration of TmDOTA-4AmC-, 200 μL of a 2-mM stock solution (corresponds to ∼0.2 mM agent in plasma), reduced the total water signal in the kidney papilla by 45% 3 min after the a bolus injection. The results show that the OPARACHEE methodology employing low-amplitude RF trains can detect paramagnetic exchanging agents in vivo.

Original languageEnglish (US)
Pages (from-to)650-655
Number of pages6
JournalMagnetic resonance in medicine
Volume58
Issue number4
DOIs
StatePublished - Oct 2007

Keywords

  • Contrast
  • Exchange
  • Low B WALTZ-16
  • OPARACHEE
  • PARACEST

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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