MRI shows abnormal white matter maturation in classical holoprosencephaly

A. J. Barkovich; E. M. Simon; O. A. Glenn; N. J. Clegg; S. L. Kinsman; M. Delgado; J. S. Hahn

doi:10.1212/01.WNL.0000038354.10891.0E

MRI shows abnormal white matter maturation in classical holoprosencephaly

A. J. Barkovich, E. M. Simon, O. A. Glenn, N. J. Clegg, S. L. Kinsman, M. Delgado, J. S. Hahn

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Abstract

In an attempt to assess white matter maturation in holoprosencephaly (HPE), MRI scans of 47 patients with HPE were retrospectively reviewed. White matter maturation was delayed in 25/47 patients, including 24/29 patients with classic HPE who were ≤ 12 months old at the time of imaging. Of interest, all six patients with the middle interhemispheric (MIH) variant of HPE had normal myelination, regardless of age. This study provides further evidence that the classic and MIH variants of HPE have different underlying causes.

Original language	English (US)
Pages (from-to)	1968-1971
Number of pages	4
Journal	Neurology
Volume	59
Issue number	12
DOIs	https://doi.org/10.1212/01.WNL.0000038354.10891.0E
State	Published - Dec 24 2002

ASJC Scopus subject areas

Clinical Neurology

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title = "MRI shows abnormal white matter maturation in classical holoprosencephaly",

abstract = "In an attempt to assess white matter maturation in holoprosencephaly (HPE), MRI scans of 47 patients with HPE were retrospectively reviewed. White matter maturation was delayed in 25/47 patients, including 24/29 patients with classic HPE who were ≤ 12 months old at the time of imaging. Of interest, all six patients with the middle interhemispheric (MIH) variant of HPE had normal myelination, regardless of age. This study provides further evidence that the classic and MIH variants of HPE have different underlying causes.",

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AU - Barkovich, A. J.

AU - Simon, E. M.

AU - Glenn, O. A.

AU - Clegg, N. J.

AU - Kinsman, S. L.

AU - Delgado, M.

AU - Hahn, J. S.

PY - 2002/12/24

Y1 - 2002/12/24

N2 - In an attempt to assess white matter maturation in holoprosencephaly (HPE), MRI scans of 47 patients with HPE were retrospectively reviewed. White matter maturation was delayed in 25/47 patients, including 24/29 patients with classic HPE who were ≤ 12 months old at the time of imaging. Of interest, all six patients with the middle interhemispheric (MIH) variant of HPE had normal myelination, regardless of age. This study provides further evidence that the classic and MIH variants of HPE have different underlying causes.

AB - In an attempt to assess white matter maturation in holoprosencephaly (HPE), MRI scans of 47 patients with HPE were retrospectively reviewed. White matter maturation was delayed in 25/47 patients, including 24/29 patients with classic HPE who were ≤ 12 months old at the time of imaging. Of interest, all six patients with the middle interhemispheric (MIH) variant of HPE had normal myelination, regardless of age. This study provides further evidence that the classic and MIH variants of HPE have different underlying causes.

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SN - 0028-3878

VL - 59

SP - 1968

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JO - Neurology

JF - Neurology

IS - 12

ER -

MRI shows abnormal white matter maturation in classical holoprosencephaly

Abstract

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