TY - JOUR
T1 - Mta, a maternally inherited cell surface antigen of the mouse, is transmitted in the egg
AU - Fischer Lindahl, K.
AU - Burki, K.
PY - 1982
Y1 - 1982
N2 - Mta is a maternally transmitted cell surface antigen found in most mouse strains. It serves as a target for unrestricted T killer cells. All 49 embryos transferred between positive and negative mothers, even as early as 10-15 hr after fertilization, developed into mice with the Mta type of their original mothers. Therefore the genetic element that determines expression of Mta must be transmitted by the egg. Mta+ and Mta- lymphocytes, coexisting for months in lethally irradiated F1 mice reconstituted with a mixture of parental bone marrow cells, retained their Mta type. Thus Mta does not spread by infection.
AB - Mta is a maternally transmitted cell surface antigen found in most mouse strains. It serves as a target for unrestricted T killer cells. All 49 embryos transferred between positive and negative mothers, even as early as 10-15 hr after fertilization, developed into mice with the Mta type of their original mothers. Therefore the genetic element that determines expression of Mta must be transmitted by the egg. Mta+ and Mta- lymphocytes, coexisting for months in lethally irradiated F1 mice reconstituted with a mixture of parental bone marrow cells, retained their Mta type. Thus Mta does not spread by infection.
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U2 - 10.1073/pnas.79.17.5362
DO - 10.1073/pnas.79.17.5362
M3 - Article
C2 - 6957869
AN - SCOPUS:0020404838
SN - 0027-8424
VL - 79
SP - 5362
EP - 5366
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 17 I
ER -