mTOR signaling in stem and progenitor cells

Delong Meng, Anderson R. Frank, Jenna L. Jewell

Research output: Contribution to journalReview article

20 Citations (Scopus)

Abstract

The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to coordinate cell growth, metabolism and autophagy. Extensive research has mapped the signaling pathways regulated by mTOR that are involved in human diseases, such as cancer, and in diabetes and ageing. Recently, however, new studies have demonstrated important roles for mTOR in promoting the differentiation of adult stem cells, driving the growth and proliferation of stem and progenitor cells, and dictating the differentiation program of multipotent stem cell populations. Here, we review these advances, providing an overview of mTOR signaling and its role in murine and human stem and progenitor cells.

Original languageEnglish (US)
Article numberdev152595
JournalDevelopment (Cambridge)
Volume145
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Sirolimus
Stem Cells
Multipotent Stem Cells
Adult Stem Cells
Autophagy
Growth
Cell Differentiation
Intercellular Signaling Peptides and Proteins
Food
Research
Population
Neoplasms

Keywords

  • Amino acids
  • Metabolism
  • mTOR
  • Signaling
  • Stem cell

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

Cite this

mTOR signaling in stem and progenitor cells. / Meng, Delong; Frank, Anderson R.; Jewell, Jenna L.

In: Development (Cambridge), Vol. 145, No. 1, dev152595, 01.01.2018.

Research output: Contribution to journalReview article

Meng, Delong ; Frank, Anderson R. ; Jewell, Jenna L. / mTOR signaling in stem and progenitor cells. In: Development (Cambridge). 2018 ; Vol. 145, No. 1.
@article{b9e10201676c415396fc20687efb578a,
title = "mTOR signaling in stem and progenitor cells",
abstract = "The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to coordinate cell growth, metabolism and autophagy. Extensive research has mapped the signaling pathways regulated by mTOR that are involved in human diseases, such as cancer, and in diabetes and ageing. Recently, however, new studies have demonstrated important roles for mTOR in promoting the differentiation of adult stem cells, driving the growth and proliferation of stem and progenitor cells, and dictating the differentiation program of multipotent stem cell populations. Here, we review these advances, providing an overview of mTOR signaling and its role in murine and human stem and progenitor cells.",
keywords = "Amino acids, Metabolism, mTOR, Signaling, Stem cell",
author = "Delong Meng and Frank, {Anderson R.} and Jewell, {Jenna L.}",
year = "2018",
month = "1",
day = "1",
doi = "10.1242/dev.152595",
language = "English (US)",
volume = "145",
journal = "Development (Cambridge)",
issn = "0950-1991",
publisher = "Company of Biologists Ltd",
number = "1",

}

TY - JOUR

T1 - mTOR signaling in stem and progenitor cells

AU - Meng, Delong

AU - Frank, Anderson R.

AU - Jewell, Jenna L.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to coordinate cell growth, metabolism and autophagy. Extensive research has mapped the signaling pathways regulated by mTOR that are involved in human diseases, such as cancer, and in diabetes and ageing. Recently, however, new studies have demonstrated important roles for mTOR in promoting the differentiation of adult stem cells, driving the growth and proliferation of stem and progenitor cells, and dictating the differentiation program of multipotent stem cell populations. Here, we review these advances, providing an overview of mTOR signaling and its role in murine and human stem and progenitor cells.

AB - The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to coordinate cell growth, metabolism and autophagy. Extensive research has mapped the signaling pathways regulated by mTOR that are involved in human diseases, such as cancer, and in diabetes and ageing. Recently, however, new studies have demonstrated important roles for mTOR in promoting the differentiation of adult stem cells, driving the growth and proliferation of stem and progenitor cells, and dictating the differentiation program of multipotent stem cell populations. Here, we review these advances, providing an overview of mTOR signaling and its role in murine and human stem and progenitor cells.

KW - Amino acids

KW - Metabolism

KW - mTOR

KW - Signaling

KW - Stem cell

UR - http://www.scopus.com/inward/record.url?scp=85040787885&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040787885&partnerID=8YFLogxK

U2 - 10.1242/dev.152595

DO - 10.1242/dev.152595

M3 - Review article

VL - 145

JO - Development (Cambridge)

JF - Development (Cambridge)

SN - 0950-1991

IS - 1

M1 - dev152595

ER -