Mucinous adenocarcinoma of the prostate does not confer poor prognosis

Brian R. Lane, Cristina Magi-Galluzzi, Alwyn M. Reuther, Howard S. Levin, Ming Zhou, Eric A. Klein

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Objectives: To report a series of patients with mucinous (colloid) adenocarcinoma (MC) at prostatectomy who were treated at a single institution from 1987 to 2005. MC is a rare form of prostate cancer reported in some cases to have a more aggressive clinical course than conventional adenocarcinoma (AC). Methods: Radical prostatectomy specimens with mucinous features were identified from a database of 3613 consecutive patients. Each case was reviewed again by a single pathologist who confirmed the diagnosis of MC in 14 patients. MC was defined by the presence of pools of extracellular mucin in more than 25% of the tumor. Eighteen additional cases were identified in which the mucinous component occupied only a small portion of the tumor and were referred to as AC with focal mucin (AFM). The biochemical and overall survival of 26 patients with MC or AFM who had completed ≥6 months of follow-up was analyzed using Kaplan-Meier estimates. Results: No patients with MC or AFM died of disease, and 11 (91.7%) of 12 patients with MC and 9 (64.3%) of 14 patients with AFM were clinically and biochemically free of disease. No significant difference was found in biochemical recurrence or overall survival between those with MC or AFM and a matched group of patients with AC. Conclusions: We report what we believe to be the largest published series of cases of MC (n = 14) with a median overall follow-up of 6.4 years. MC appears to behave clinically in a similar fashion to AC, with no statistically significant difference in biochemical failure or survival.

Original languageEnglish (US)
Pages (from-to)825-830
Number of pages6
JournalUrology
Volume68
Issue number4
DOIs
StatePublished - Oct 1 2006

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Mucinous Adenocarcinoma
Prostate
Mucins
Adenocarcinoma
Prostatectomy
Survival
Kaplan-Meier Estimate
Colloids
Neoplasms
Prostatic Neoplasms
Research Design
Databases
Recurrence

ASJC Scopus subject areas

  • Urology

Cite this

Lane, B. R., Magi-Galluzzi, C., Reuther, A. M., Levin, H. S., Zhou, M., & Klein, E. A. (2006). Mucinous adenocarcinoma of the prostate does not confer poor prognosis. Urology, 68(4), 825-830. https://doi.org/10.1016/j.urology.2006.04.028

Mucinous adenocarcinoma of the prostate does not confer poor prognosis. / Lane, Brian R.; Magi-Galluzzi, Cristina; Reuther, Alwyn M.; Levin, Howard S.; Zhou, Ming; Klein, Eric A.

In: Urology, Vol. 68, No. 4, 01.10.2006, p. 825-830.

Research output: Contribution to journalArticle

Lane, BR, Magi-Galluzzi, C, Reuther, AM, Levin, HS, Zhou, M & Klein, EA 2006, 'Mucinous adenocarcinoma of the prostate does not confer poor prognosis', Urology, vol. 68, no. 4, pp. 825-830. https://doi.org/10.1016/j.urology.2006.04.028
Lane BR, Magi-Galluzzi C, Reuther AM, Levin HS, Zhou M, Klein EA. Mucinous adenocarcinoma of the prostate does not confer poor prognosis. Urology. 2006 Oct 1;68(4):825-830. https://doi.org/10.1016/j.urology.2006.04.028
Lane, Brian R. ; Magi-Galluzzi, Cristina ; Reuther, Alwyn M. ; Levin, Howard S. ; Zhou, Ming ; Klein, Eric A. / Mucinous adenocarcinoma of the prostate does not confer poor prognosis. In: Urology. 2006 ; Vol. 68, No. 4. pp. 825-830.
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