Mucinous tubular and spindle cell carcinoma of the kidney: Diagnosis by fine needle aspiration and review of the literature

Jiang Huimiao, Julie Chepovetsky, Ming Zhou, Wei Sun, Aylin Simsir, Deirdre Cohen, Allen Leung

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Renal mucinous tubular and spindle cell carcinoma (MTSCC) was recently described as a distinct subtype of renal cell carcinoma (RCC) in the 2004 World Health Organization classification of kidney tumors. MTSCC is a rare low grade malignancy with < 100 cases reported in the literature. To the best of our knowledge, there are 5 case reports with a total of 6 patients describing its diagnosis by fine needle aspiration (FNA). All of these cases were diagnosed as conventional RCC on FNA. Subsequent excisions proved them to be MTSCC. We herein report a case in a 67-year-old male. He presented with abdominal pain and was found to have a new colon adenocarcinoma with metastasis to the liver and lungs. The extent of disease made the patient ineligible for surgical excision, and he received chemotherapy. Work-up also revealed a kidney mass which was later biopsied by FNA and core biopsy. The tumor was composed of epithelial and spindled cell components embedded in a myxoid background. It was positive for CK7, AMCAR, vimentin, and epithelial membrane antigen. The tumor was diagnosed as MTSCC. One year later the kidney mass remained stable. However, the patient developed new metastasis to the liver from colonic primary. The kidney mass was not resected. Although rarely encountered in FNA cytology of the kidney, we believe the cytologic features of this tumor are distinctive and are different from conventional and other subtypes of RCC. Therefore, its accurate diagnosis on FNA is possible once pathologists are aware that MTSCC should be considered in the differential diagnosis of kidney tumors.

Original languageEnglish (US)
Article number171135
JournalCytoJournal
Volume12
Issue number1
DOIs
StatePublished - Jan 1 2015

Fingerprint

Fine Needle Biopsy
Carcinoma
Kidney
Renal Cell Carcinoma
Neoplasms
Neoplasm Metastasis
Mucin-1
Liver
Vimentin
Cellular Structures
Abdominal Pain
Cell Biology
Colon
Adenocarcinoma
Differential Diagnosis
Epithelial Cells
Drug Therapy
Lung

Keywords

  • Fine needle aspiration
  • kidney
  • renal mucinous tubular spindle cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Mucinous tubular and spindle cell carcinoma of the kidney : Diagnosis by fine needle aspiration and review of the literature. / Huimiao, Jiang; Chepovetsky, Julie; Zhou, Ming; Sun, Wei; Simsir, Aylin; Cohen, Deirdre; Leung, Allen.

In: CytoJournal, Vol. 12, No. 1, 171135, 01.01.2015.

Research output: Contribution to journalArticle

Huimiao, Jiang ; Chepovetsky, Julie ; Zhou, Ming ; Sun, Wei ; Simsir, Aylin ; Cohen, Deirdre ; Leung, Allen. / Mucinous tubular and spindle cell carcinoma of the kidney : Diagnosis by fine needle aspiration and review of the literature. In: CytoJournal. 2015 ; Vol. 12, No. 1.
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