Mucosal defense and repair: Role of prostaglandins in the stomach and duodenum

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

When considering the diseases of the stomach and duodenum, peptic ulcer disease has been the one of greatest clinical impact. Although there are several components that contribute mechanistically to ulcer disease, it is recognized that gastroduodenal mucosal prostaglandins play a central pathogenic role, especially in ulcers related to the use of NSAIDs. As a result of understanding the mechanisms of NSAID-induced ulceration, the crucial function that gastroduodenal mucosal prostaglandins have in mucosal defense and repair is appreciated. It now is held widely that mucosal prostaglandin deficiency increases susceptibility to ulcer formation and that exogenous administration of supplemental prostaglandins reduces ulcer risk. This article reviews the role that mucosal prostaglandins play in defense of the gastric and duodenal mucosa against injury and ulceration.

Original languageEnglish (US)
Pages (from-to)877-894
Number of pages18
JournalGastroenterology Clinics of North America
Volume30
Issue number4
DOIs
StatePublished - 2001

Fingerprint

Duodenum
Prostaglandins
Stomach
Ulcer
Non-Steroidal Anti-Inflammatory Agents
Stomach Diseases
Gastric Mucosa
Peptic Ulcer
Wounds and Injuries

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Mucosal defense and repair : Role of prostaglandins in the stomach and duodenum. / Cryer, Byron.

In: Gastroenterology Clinics of North America, Vol. 30, No. 4, 2001, p. 877-894.

Research output: Contribution to journalArticle

@article{8a17829a25414d2dad2b90bccb5425fc,
title = "Mucosal defense and repair: Role of prostaglandins in the stomach and duodenum",
abstract = "When considering the diseases of the stomach and duodenum, peptic ulcer disease has been the one of greatest clinical impact. Although there are several components that contribute mechanistically to ulcer disease, it is recognized that gastroduodenal mucosal prostaglandins play a central pathogenic role, especially in ulcers related to the use of NSAIDs. As a result of understanding the mechanisms of NSAID-induced ulceration, the crucial function that gastroduodenal mucosal prostaglandins have in mucosal defense and repair is appreciated. It now is held widely that mucosal prostaglandin deficiency increases susceptibility to ulcer formation and that exogenous administration of supplemental prostaglandins reduces ulcer risk. This article reviews the role that mucosal prostaglandins play in defense of the gastric and duodenal mucosa against injury and ulceration.",
author = "Byron Cryer",
year = "2001",
doi = "10.1016/S0889-8553(05)70218-1",
language = "English (US)",
volume = "30",
pages = "877--894",
journal = "Gastroenterology Clinics of North America",
issn = "0889-8553",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Mucosal defense and repair

T2 - Role of prostaglandins in the stomach and duodenum

AU - Cryer, Byron

PY - 2001

Y1 - 2001

N2 - When considering the diseases of the stomach and duodenum, peptic ulcer disease has been the one of greatest clinical impact. Although there are several components that contribute mechanistically to ulcer disease, it is recognized that gastroduodenal mucosal prostaglandins play a central pathogenic role, especially in ulcers related to the use of NSAIDs. As a result of understanding the mechanisms of NSAID-induced ulceration, the crucial function that gastroduodenal mucosal prostaglandins have in mucosal defense and repair is appreciated. It now is held widely that mucosal prostaglandin deficiency increases susceptibility to ulcer formation and that exogenous administration of supplemental prostaglandins reduces ulcer risk. This article reviews the role that mucosal prostaglandins play in defense of the gastric and duodenal mucosa against injury and ulceration.

AB - When considering the diseases of the stomach and duodenum, peptic ulcer disease has been the one of greatest clinical impact. Although there are several components that contribute mechanistically to ulcer disease, it is recognized that gastroduodenal mucosal prostaglandins play a central pathogenic role, especially in ulcers related to the use of NSAIDs. As a result of understanding the mechanisms of NSAID-induced ulceration, the crucial function that gastroduodenal mucosal prostaglandins have in mucosal defense and repair is appreciated. It now is held widely that mucosal prostaglandin deficiency increases susceptibility to ulcer formation and that exogenous administration of supplemental prostaglandins reduces ulcer risk. This article reviews the role that mucosal prostaglandins play in defense of the gastric and duodenal mucosa against injury and ulceration.

UR - http://www.scopus.com/inward/record.url?scp=0035198746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035198746&partnerID=8YFLogxK

U2 - 10.1016/S0889-8553(05)70218-1

DO - 10.1016/S0889-8553(05)70218-1

M3 - Article

C2 - 11764533

AN - SCOPUS:0035198746

VL - 30

SP - 877

EP - 894

JO - Gastroenterology Clinics of North America

JF - Gastroenterology Clinics of North America

SN - 0889-8553

IS - 4

ER -