Multi-channel RF system for MRI-guided transurethral ultrasound thermal therapy

Nicolas Yak, Matthew Asselin, Rajiv Chopra, Michael Bronskill

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

MRI-guided transurethral ultrasound thermal therapy is an approach to treating localized prostate cancer which targets precise deposition of thermal energy within a confined region of the gland. This treatment requires a system incorporating a heating applicator with multiple planar ultrasound transducers and associated RF electronics to control individual elements independently in order to achieve accurate 3D treatment. We report the design, construction, and characterization of a prototype multi-channel system capable of controlling 16 independent RF signals for a 16-element heating applicator. The main components are a control computer, microcontroller, and a 16-channel signal generator with 16 amplifiers, each incorporating a low-pass filter and transmitted/reflected power detection circuit. Each channel can deliver from 0.5 to 10W of electrical power and good linearity from 3 to 12MHz. Harmonic RF signals near the Larmor frequency of a 1.5T MRI were measured to be below -30dBm and heating experiments within the 1.5T MR system showed no significant decrease in SNR of the temperature images. The frequency and power for all 16 channels could be changed in less than 250ms, which was sufficiently rapid for proper performance of the control algorithms. A common backplane design was chosen which enabled an inexpensive, modular approach for each channel resulting in an overall system with minimal footprint.

Original languageEnglish (US)
Title of host publication8th International Symposium on Therapeutic Ultrasound
Pages382-386
Number of pages5
DOIs
StatePublished - Jul 21 2009
Event8th International Symposium on Therapeutic Ultrasound - Minneapolis, MN, United States
Duration: Sep 10 2008Sep 13 2008

Publication series

NameAIP Conference Proceedings
Volume1113
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other8th International Symposium on Therapeutic Ultrasound
CountryUnited States
CityMinneapolis, MN
Period9/10/089/13/08

Keywords

  • Amplifier
  • MRI-guided
  • Multi-channel
  • Prostate
  • RF
  • Signal generator
  • Transurethral
  • Ultrasound thermal therapy

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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  • Cite this

    Yak, N., Asselin, M., Chopra, R., & Bronskill, M. (2009). Multi-channel RF system for MRI-guided transurethral ultrasound thermal therapy. In 8th International Symposium on Therapeutic Ultrasound (pp. 382-386). (AIP Conference Proceedings; Vol. 1113). https://doi.org/10.1063/1.3131453