Multi-chromatic pH-activatable 19F-MRI nanoprobes with binary ON/OFF pH transitions and chemical-shift barcodes

Xiaonan Huang, Gang Huang, Shanrong Zhang, Koji Sagiyama, Osamu Togao, Xinpeng Ma, Yiguang Wang, Yang Li, Todd C. Soesbe, Baran D. Sumer, Masaya Takahashi, A. Dean Sherry, Jinming Gao

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Imaging all the people: Using ionizable diblock copolymers a series of nanoprobes encoded with different 19F reporters for specific pH transitions is prepared for use in MRI. The pH response of the nanoprobes is extremely sharp (ΔpHON/OFF≈0.25 pH), and results from the disassembly of polymer micelles (see scheme). A collection of three nanoprobes provides the proof of concept and allows for a qualitative measurement of environmental pH values.

Original languageEnglish (US)
Pages (from-to)8074-8078
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number31
DOIs
StatePublished - Jul 29 2013

    Fingerprint

Keywords

  • F MRI
  • imaging agents
  • micelles
  • pH imaging
  • polymers

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this