Multi-chromatic pH-activatable 19F-MRI nanoprobes with binary ON/OFF pH transitions and chemical-shift barcodes

Xiaonan Huang; Gang Huang; Shanrong Zhang; Koji Sagiyama; Osamu Togao; Xinpeng Ma; Yiguang Wang; Yang Li; Todd C. Soesbe; Baran D. Sumer; Masaya Takahashi; A. Dean Sherry; Jinming Gao

doi:10.1002/anie.201301135

Multi-chromatic pH-activatable ¹⁹F-MRI nanoprobes with binary ON/OFF pH transitions and chemical-shift barcodes

Xiaonan Huang, Gang Huang, Shanrong Zhang, Koji Sagiyama, Osamu Togao, Xinpeng Ma, Yiguang Wang, Yang Li, Todd C. Soesbe, Baran D. Sumer, Masaya Takahashi, A. Dean Sherry, Jinming Gao

Research output: Contribution to journal › Article › peer-review

95 Scopus citations

Abstract

Imaging all the people: Using ionizable diblock copolymers a series of nanoprobes encoded with different ¹⁹F reporters for specific pH transitions is prepared for use in MRI. The pH response of the nanoprobes is extremely sharp (ΔpH_ON/OFF≈0.25 pH), and results from the disassembly of polymer micelles (see scheme). A collection of three nanoprobes provides the proof of concept and allows for a qualitative measurement of environmental pH values.

Original language	English (US)
Pages (from-to)	8074-8078
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	31
DOIs	https://doi.org/10.1002/anie.201301135
State	Published - Jul 29 2013

Keywords

F MRI
imaging agents
micelles
pH imaging
polymers

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.201301135

Cite this

Huang, X., Huang, G., Zhang, S., Sagiyama, K., Togao, O., Ma, X., Wang, Y., Li, Y., Soesbe, T. C., Sumer, B. D., Takahashi, M., Sherry, A. D., & Gao, J. (2013). Multi-chromatic pH-activatable ¹⁹F-MRI nanoprobes with binary ON/OFF pH transitions and chemical-shift barcodes. Angewandte Chemie - International Edition, 52(31), 8074-8078. https://doi.org/10.1002/anie.201301135

@article{a182997d34f244c685eb8e8ea49088c6,

title = "Multi-chromatic pH-activatable 19F-MRI nanoprobes with binary ON/OFF pH transitions and chemical-shift barcodes",

abstract = "Imaging all the people: Using ionizable diblock copolymers a series of nanoprobes encoded with different 19F reporters for specific pH transitions is prepared for use in MRI. The pH response of the nanoprobes is extremely sharp (ΔpHON/OFF≈0.25 pH), and results from the disassembly of polymer micelles (see scheme). A collection of three nanoprobes provides the proof of concept and allows for a qualitative measurement of environmental pH values.",

keywords = "F MRI, imaging agents, micelles, pH imaging, polymers",

author = "Xiaonan Huang and Gang Huang and Shanrong Zhang and Koji Sagiyama and Osamu Togao and Xinpeng Ma and Yiguang Wang and Yang Li and Soesbe, {Todd C.} and Sumer, {Baran D.} and Masaya Takahashi and Sherry, {A. Dean} and Jinming Gao",

year = "2013",

month = jul,

day = "29",

doi = "10.1002/anie.201301135",

language = "English (US)",

volume = "52",

pages = "8074--8078",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "31",

}

TY - JOUR

T1 - Multi-chromatic pH-activatable 19F-MRI nanoprobes with binary ON/OFF pH transitions and chemical-shift barcodes

AU - Huang, Xiaonan

AU - Huang, Gang

AU - Zhang, Shanrong

AU - Sagiyama, Koji

AU - Togao, Osamu

AU - Ma, Xinpeng

AU - Wang, Yiguang

AU - Li, Yang

AU - Soesbe, Todd C.

AU - Sumer, Baran D.

AU - Takahashi, Masaya

AU - Sherry, A. Dean

AU - Gao, Jinming

PY - 2013/7/29

Y1 - 2013/7/29

N2 - Imaging all the people: Using ionizable diblock copolymers a series of nanoprobes encoded with different 19F reporters for specific pH transitions is prepared for use in MRI. The pH response of the nanoprobes is extremely sharp (ΔpHON/OFF≈0.25 pH), and results from the disassembly of polymer micelles (see scheme). A collection of three nanoprobes provides the proof of concept and allows for a qualitative measurement of environmental pH values.

AB - Imaging all the people: Using ionizable diblock copolymers a series of nanoprobes encoded with different 19F reporters for specific pH transitions is prepared for use in MRI. The pH response of the nanoprobes is extremely sharp (ΔpHON/OFF≈0.25 pH), and results from the disassembly of polymer micelles (see scheme). A collection of three nanoprobes provides the proof of concept and allows for a qualitative measurement of environmental pH values.

KW - F MRI

KW - imaging agents

KW - micelles

KW - pH imaging

KW - polymers

UR - http://www.scopus.com/inward/record.url?scp=84880815965&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880815965&partnerID=8YFLogxK

U2 - 10.1002/anie.201301135

DO - 10.1002/anie.201301135

M3 - Article

C2 - 23788453

AN - SCOPUS:84880815965

SN - 1433-7851

VL - 52

SP - 8074

EP - 8078

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 31

ER -