Multi-color Raman nanotags for tumor cell biomarker detection

James Nyagilo, Ming Xiao, Xiankai Sun, Digant P. Davé

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Citations (Scopus)

Abstract

We report the synthesis and characterization of multi-color gold nanoparticle based tags (Raman Nanotags) for molecular imaging. The multi-color Raman Nanotags are PEGylated gold nanoparticles (AuNPs) encapsulating a Raman reporter dyes which can be functionalized with any ligand of interest for targeted molecular imaging. The Raman Nanotags synthesized with 65 nm gold nanoparticles exhibit the largest surface enhanced Raman scattering (SERS) signal. Results are presented quantify the measured SERS signal, dynamic range, reproducibility, and stability of Raman Nanotags. In vitro cell culture experiments for targeted biomarker detection using functionalized Raman Nanotags are also presented.

Original languageEnglish (US)
Title of host publicationProceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
Pages6314-6317
Number of pages4
DOIs
StatePublished - 2009
Event31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 - Minneapolis, MN, United States
Duration: Sep 2 2009Sep 6 2009

Other

Other31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009
CountryUnited States
CityMinneapolis, MN
Period9/2/099/6/09

Fingerprint

Biomarkers
Tumor Biomarkers
Gold
Nanoparticles
Molecular imaging
Tumors
Molecular Imaging
Raman Spectrum Analysis
Color
Cells
Raman scattering
Cell culture
Coloring Agents
Dyes
Cell Culture Techniques
Ligands
Experiments

ASJC Scopus subject areas

  • Cell Biology
  • Developmental Biology
  • Biomedical Engineering
  • Medicine(all)

Cite this

Nyagilo, J., Xiao, M., Sun, X., & Davé, D. P. (2009). Multi-color Raman nanotags for tumor cell biomarker detection. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009 (pp. 6314-6317). [5332780] https://doi.org/10.1109/IEMBS.2009.5332780

Multi-color Raman nanotags for tumor cell biomarker detection. / Nyagilo, James; Xiao, Ming; Sun, Xiankai; Davé, Digant P.

Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 6314-6317 5332780.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Nyagilo, J, Xiao, M, Sun, X & Davé, DP 2009, Multi-color Raman nanotags for tumor cell biomarker detection. in Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009., 5332780, pp. 6314-6317, 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009, Minneapolis, MN, United States, 9/2/09. https://doi.org/10.1109/IEMBS.2009.5332780
Nyagilo J, Xiao M, Sun X, Davé DP. Multi-color Raman nanotags for tumor cell biomarker detection. In Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. p. 6314-6317. 5332780 https://doi.org/10.1109/IEMBS.2009.5332780
Nyagilo, James ; Xiao, Ming ; Sun, Xiankai ; Davé, Digant P. / Multi-color Raman nanotags for tumor cell biomarker detection. Proceedings of the 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society: Engineering the Future of Biomedicine, EMBC 2009. 2009. pp. 6314-6317
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