Multi-omics reveals microbiome, host gene expression, and immune landscape in gastric carcinogenesis

Chan Hyuk Park, Changjin Hong, A. reum Lee, Jaeyun Sung, Tae Hyun Hwang

Research output: Contribution to journalArticlepeer-review

Abstract

To date, there has been no multi-omic analysis characterizing the intricate relationships between the intragastric microbiome and gastric mucosal gene expression in gastric carcinogenesis. Using multi-omic approaches, we provide a comprehensive view of the connections between the microbiome and host gene expression in distinct stages of gastric carcinogenesis (i.e., healthy, gastritis, cancer). Our integrative analysis uncovers various associations specific to disease states. For example, uniquely in gastritis, Helicobacteraceae is highly correlated with the expression of FAM3D, which has been previously implicated in gastrointestinal inflammation. In addition, in gastric cancer but not in adjacent gastritis, Lachnospiraceae is highly correlated with the expression of UBD, which regulates mitosis and cell cycle time. Furthermore, lower abundances of B cell signatures in gastric cancer compared to gastritis may suggest a previously unidentified immune evasion process in gastric carcinogenesis. Our study provides the most comprehensive description of microbial, host transcriptomic, and immune cell factors of the gastric carcinogenesis pathway.

Original languageEnglish (US)
Article number103956
JournaliScience
Volume25
Issue number3
DOIs
StatePublished - Mar 18 2022
Externally publishedYes

Keywords

  • Cellular physiology
  • Microbiome
  • Omics

ASJC Scopus subject areas

  • General

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