Multi-site study of diffusion metric variability: Effects of site, vendor, field strength, and echo time on regions-of-interest and histogram-bin analyses

K. G. Helmer, M. C. Chou, R. I. Preciado, B. Gimi, N. K. Rollins, A. Song, J. Turner, S. Mori

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

It is now common for magnetic-resonance-imaging (MRI) based multi-site trials to include diffusion-weighted imaging (DWI) as part of the protocol. It is also common for these sites to possess MR scanners of different manufacturers, different software and hardware, and different software licenses. These differences mean that scanners may not be able to acquire data with the same number of gradient amplitude values and number of available gradient directions. Variability can also occur in achievable b-values and minimum echo times. The challenge of a multi-site study then, is to create a common protocol by understanding and then minimizing the effects of scanner variability and identifying reliable and accurate diffusion metrics. This study describes the effect of site, scanner vendor, field strength, and TE on two diffusion metrics: the first moment of the diffusion tensor field (mean diffusivity, MD), and the fractional anisotropy (FA) using two common analyses (region-of-interest and mean-bin value of whole brain histograms). The goal of the study was to identify sources of variability in diffusion-sensitized imaging and their influence on commonly reported metrics. The results demonstrate that the site, vendor, field strength, and echo time all contribute to variability in FA and MD, though to different extent. We conclude that characterization of the variability of DTI metrics due to site, vendor, field strength, and echo time is a worthwhile step in the construction of multi-center trials.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging
PublisherSPIE
Volume9788
ISBN (Electronic)9781510600232
DOIs
StatePublished - 2016
EventMedical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging - San Diego, United States
Duration: Mar 1 2016Mar 3 2016

Other

OtherMedical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging
CountryUnited States
CitySan Diego
Period3/1/163/3/16

Fingerprint

Bins
histograms
field strength
echoes
scanners
Anisotropy
diffusivity
Software
Imaging techniques
computer programs
gradients
anisotropy
Licensure
brain
magnetic resonance
hardware
Magnetic resonance
Magnetic Resonance Imaging
tensors
moments

Keywords

  • Calibration
  • Diffusion
  • MRI
  • Multi-site study

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

Helmer, K. G., Chou, M. C., Preciado, R. I., Gimi, B., Rollins, N. K., Song, A., ... Mori, S. (2016). Multi-site study of diffusion metric variability: Effects of site, vendor, field strength, and echo time on regions-of-interest and histogram-bin analyses. In Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging (Vol. 9788). [97882U] SPIE. https://doi.org/10.1117/12.2217445

Multi-site study of diffusion metric variability : Effects of site, vendor, field strength, and echo time on regions-of-interest and histogram-bin analyses. / Helmer, K. G.; Chou, M. C.; Preciado, R. I.; Gimi, B.; Rollins, N. K.; Song, A.; Turner, J.; Mori, S.

Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 9788 SPIE, 2016. 97882U.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Helmer, KG, Chou, MC, Preciado, RI, Gimi, B, Rollins, NK, Song, A, Turner, J & Mori, S 2016, Multi-site study of diffusion metric variability: Effects of site, vendor, field strength, and echo time on regions-of-interest and histogram-bin analyses. in Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging. vol. 9788, 97882U, SPIE, Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging, San Diego, United States, 3/1/16. https://doi.org/10.1117/12.2217445
Helmer KG, Chou MC, Preciado RI, Gimi B, Rollins NK, Song A et al. Multi-site study of diffusion metric variability: Effects of site, vendor, field strength, and echo time on regions-of-interest and histogram-bin analyses. In Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 9788. SPIE. 2016. 97882U https://doi.org/10.1117/12.2217445
Helmer, K. G. ; Chou, M. C. ; Preciado, R. I. ; Gimi, B. ; Rollins, N. K. ; Song, A. ; Turner, J. ; Mori, S. / Multi-site study of diffusion metric variability : Effects of site, vendor, field strength, and echo time on regions-of-interest and histogram-bin analyses. Medical Imaging 2016: Biomedical Applications in Molecular, Structural, and Functional Imaging. Vol. 9788 SPIE, 2016.
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