Multicenter experience of ABO-incompatible pediatric cardiac transplantation

S. L. Roche, M. Burch, J. O'Sullivan, J. Wallis, G. Parry, R. Kirk, M. Elliot, N. Shaw, J. Flett, J. R.L. Hamilton, A. Hasan

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Although ABO blood group incompatible cardiac transplantation in neonates and infants reduces waiting list mortality without compromising outcome, the technique has not been adopted by all centers, and to date Toronto remains the only center to have published results from a large case series. We present a review of ABO-incompatible heart transplantation in the United Kingdom (UK) where current recipient selection criteria differ somewhat from those used in the United States (US) and Canada. Between February 2000 and November 2006, 21 ABO-incompatible cardiac transplants were performed in children aged 2-40 months (median 10.0). Immunosuppression followed standard regimens. Pretransplant donor-specific isohemagglutinins of >1:4, (the UNOS cutoff), were present in five patients and reduced by plasma exchange. After transplantation, 19/21 recipients demonstrated persisting deficiency of donor-specific isohemagglutinins. Significant donor-specific isohemagglutinins levels were detected repeatedly in 2/21 recipients who have shown no clinical or biopsy evidence of rejection. All recipients survive without retransplantation and there have been no episodes of humoral rejection. We conclude it is possible for other centers to replicate the excellent results achieved in Toronto and that ABO-incompatible transplantation may be performed successfully in some patients beyond infancy with established isohemagglutinin production providing preoperative antibody removing strategies are used.

Original languageEnglish (US)
Pages (from-to)208-215
Number of pages8
JournalAmerican Journal of Transplantation
Volume8
Issue number1
DOIs
StatePublished - Jan 1 2008

Fingerprint

Hemagglutinins
Heart Transplantation
Pediatrics
Tissue Donors
Transplantation
Plasma Exchange
Waiting Lists
Blood Group Antigens
Immunosuppression
Patient Selection
Canada
Newborn Infant
Transplants
Biopsy
Mortality
Antibodies

Keywords

  • ABO incompatibility
  • Cardiac transplant
  • Heart
  • Pediatric heart transplantation
  • Pediatric recipients

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

Cite this

Roche, S. L., Burch, M., O'Sullivan, J., Wallis, J., Parry, G., Kirk, R., ... Hasan, A. (2008). Multicenter experience of ABO-incompatible pediatric cardiac transplantation. American Journal of Transplantation, 8(1), 208-215. https://doi.org/10.1111/j.1600-6143.2007.02040.x

Multicenter experience of ABO-incompatible pediatric cardiac transplantation. / Roche, S. L.; Burch, M.; O'Sullivan, J.; Wallis, J.; Parry, G.; Kirk, R.; Elliot, M.; Shaw, N.; Flett, J.; Hamilton, J. R.L.; Hasan, A.

In: American Journal of Transplantation, Vol. 8, No. 1, 01.01.2008, p. 208-215.

Research output: Contribution to journalArticle

Roche, SL, Burch, M, O'Sullivan, J, Wallis, J, Parry, G, Kirk, R, Elliot, M, Shaw, N, Flett, J, Hamilton, JRL & Hasan, A 2008, 'Multicenter experience of ABO-incompatible pediatric cardiac transplantation', American Journal of Transplantation, vol. 8, no. 1, pp. 208-215. https://doi.org/10.1111/j.1600-6143.2007.02040.x
Roche, S. L. ; Burch, M. ; O'Sullivan, J. ; Wallis, J. ; Parry, G. ; Kirk, R. ; Elliot, M. ; Shaw, N. ; Flett, J. ; Hamilton, J. R.L. ; Hasan, A. / Multicenter experience of ABO-incompatible pediatric cardiac transplantation. In: American Journal of Transplantation. 2008 ; Vol. 8, No. 1. pp. 208-215.
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