Multifaceted role of branched-chain amino acid metabolism in cancer

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Metabolic reprogramming fulfils increased nutrient demands and regulates numerous oncogenic processes in tumors, leading to tumor malignancy. Branched-chain amino acids (BCAAs, i.e., valine, leucine, and isoleucine) function as nitrogen donors to generate macromolecules such as nucleotides and are indispensable for human cancer cell growth. The cell-autonomous and non-autonomous roles of altered BCAA metabolism have been implicated in cancer progression and the key proteins in the BCAA metabolic pathway serve as possible prognostic and diagnostic biomarkers in human cancers. Here we summarize how BCAA metabolic reprogramming is regulated in cancer cells and how it influences cancer progression.

Original languageEnglish (US)
Pages (from-to)6747-6756
Number of pages10
JournalOncogene
Volume39
Issue number44
DOIs
StatePublished - Oct 29 2020

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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