Multifaceted role of the ubiquitin ligase Itch in immune regulation

K. Venuprasad, Minghui Zeng, Scott L. Baughan, Ramin Massoumi

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differentiation and immune tolerance. Also, Itch cooperates with deubiquitinating enzymes such as A20 and Cyld to terminate NF-κB signaling and prevent chronic inflammation. This review summarizes recent advances that highlight Itch's role in lymphocyte function and explores recent insights regarding its role as a regulator of inflammatory signaling.

Original languageEnglish (US)
Pages (from-to)452-460
Number of pages9
JournalImmunology and Cell Biology
Volume93
Issue number5
DOIs
StatePublished - May 28 2015
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

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