Multifaceted role of the ubiquitin ligase Itch in immune regulation

K. Venuprasad, Minghui Zeng, Scott L. Baughan, Ramin Massoumi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The HECT-type E3 ligase Itch is increasingly being shown to have a vital role in immune regulation. Itch deficiency leads to deleterious inflammatory disorders both in mice and humans. By adding ubiquitin to the key signaling intermediates, Itch functions as a critical regulator of lymphocyte-cell activation, differentiation and immune tolerance. Also, Itch cooperates with deubiquitinating enzymes such as A20 and Cyld to terminate NF-κB signaling and prevent chronic inflammation. This review summarizes recent advances that highlight Itch's role in lymphocyte function and explores recent insights regarding its role as a regulator of inflammatory signaling.

Original languageEnglish (US)
Pages (from-to)452-460
Number of pages9
JournalImmunology and Cell Biology
Volume93
Issue number5
DOIs
StatePublished - May 28 2015
Externally publishedYes

Fingerprint

Immune Tolerance
Ubiquitin-Protein Ligases
Ligases
Lymphocyte Activation
Ubiquitin
Cell Differentiation
Lymphocytes
Inflammation
Deubiquitinating Enzymes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Cell Biology

Cite this

Multifaceted role of the ubiquitin ligase Itch in immune regulation. / Venuprasad, K.; Zeng, Minghui; Baughan, Scott L.; Massoumi, Ramin.

In: Immunology and Cell Biology, Vol. 93, No. 5, 28.05.2015, p. 452-460.

Research output: Contribution to journalArticle

Venuprasad, K. ; Zeng, Minghui ; Baughan, Scott L. ; Massoumi, Ramin. / Multifaceted role of the ubiquitin ligase Itch in immune regulation. In: Immunology and Cell Biology. 2015 ; Vol. 93, No. 5. pp. 452-460.
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