Multifetal pregnancy may increase the risk for severe maternal and neonatal vitamin D deficiency

Research output: Contribution to journalArticle

2 Scopus citations


Vitamin D deficiency is prevalent in pregnant women. This deficiency could be exaggerated in multifetal pregnancies by the increased demand on maternal stores of vitamin D. We present 2 cases in which hypocalcemia and secondary hyperparathyroidism occurred in 2 sets of twins from mothers with vitamin D deficiency. The first mother had gastric bypass surgery and Crohn disease. The second mother had no apparent cause of vitamin D deficiency. Both women had iron deficiency anemia and lived in Northeastern United States. We speculate that in twins, the demand for 25-hydroxyvitamin D by 2 fetuses could deplete the 25-hydroxyvitamin D stores in a mother.

Original languageEnglish (US)
Pages (from-to)172-175
Number of pages4
Issue number4
Publication statusPublished - Jul 2008


  • Deficiency
  • Hypocalcemia
  • Multifetal
  • Pregnancy
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

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