Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

Norased Nasongkla; Erik Bey; Jimin Ren; Hua Ai; Chalermchai Khemtong; Jagadeesh Setti Guthi; Shook Fong Chin; A. Dean Sherry; David A. Boothman; Jinming Gao

doi:10.1021/nl061412u

Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

Norased Nasongkla, Erik Bey, Jimin Ren, Hua Ai, Chalermchai Khemtong, Jagadeesh Setti Guthi, Shook Fong Chin, A. Dean Sherry, David A. Boothman, Jinming Gao

Research output: Contribution to journal › Article › peer-review

1156 Scopus citations

Abstract

We describe the development of multifunctional polymeric micelles with cancer-targeting capability via α_vβ₃ integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to α_vβ₃-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and α_vβ₃-specific cytotoxic response of these multifunctional polymeric micelles.

Original language	English (US)
Pages (from-to)	2427-2430
Number of pages	4
Journal	Nano Letters
Volume	6
Issue number	11
DOIs	https://doi.org/10.1021/nl061412u
State	Published - Nov 2006

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl061412u

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abstract = "We describe the development of multifunctional polymeric micelles with cancer-targeting capability via αvβ3 integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to αvβ3-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and αvβ3-specific cytotoxic response of these multifunctional polymeric micelles.",

author = "Norased Nasongkla and Erik Bey and Jimin Ren and Hua Ai and Chalermchai Khemtong and Guthi, {Jagadeesh Setti} and Chin, {Shook Fong} and Sherry, {A. Dean} and Boothman, {David A.} and Jinming Gao",

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AU - Nasongkla, Norased

AU - Bey, Erik

AU - Ren, Jimin

AU - Ai, Hua

AU - Khemtong, Chalermchai

AU - Guthi, Jagadeesh Setti

AU - Chin, Shook Fong

AU - Sherry, A. Dean

AU - Boothman, David A.

AU - Gao, Jinming

PY - 2006/11

Y1 - 2006/11

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AB - We describe the development of multifunctional polymeric micelles with cancer-targeting capability via αvβ3 integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to αvβ3-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and αvβ3-specific cytotoxic response of these multifunctional polymeric micelles.

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Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

Abstract

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