Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

Norased Nasongkla, Erik Bey, Jimin Ren, Hua Ai, Chalermchai Khemtong, Jagadeesh Setti Guthi, Shook Fong Chin, A. Dean Sherry, David A. Boothman, Jinming Gao

Research output: Contribution to journalArticle

1029 Scopus citations

Abstract

We describe the development of multifunctional polymeric micelles with cancer-targeting capability via αvβ3 integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to αvβ3-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and αvβ3-specific cytotoxic response of these multifunctional polymeric micelles.

Original languageEnglish (US)
Pages (from-to)2427-2430
Number of pages4
JournalNano Letters
Volume6
Issue number11
DOIs
Publication statusPublished - Nov 2006

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ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

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