Multigenic regulation of the primary immune response to ovalbumin in mice

Martha Turner Lubet, John R. Kettman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

At least four genes regulate the primary immune response to ovalbumin in mice. The ability to be sensitized to transfer delayed type hypersensitivity to ovalbumin is controlled by two genes. One gene, OVA-β, is linked to the H-2 complex and maps to the left of I-E. The linkage of the other gene, OVA-Bg1, has not been determined, but it segregates independently of the Ly M locus, of the heavy chain allotype genes and of certain genes controlling coat color. At least two genes regulate the ability to respond with a primary antiovalbumin antibody response. One gene, OVA-α, is linked to the H-2 complex and maps to the right of I-E. Discordance of the minimum dose of antigen needed to elicit delayed type hypersensitivity response and antibody suggests that non-H-2 gene(s) regulating the primary antibody response are different from OVA-Bg1.

Original languageEnglish (US)
Pages (from-to)45-55
Number of pages11
JournalImmunogenetics
Volume9
Issue number1
DOIs
StatePublished - Dec 1979

Fingerprint

Ovalbumin
Genes
Antibody Formation
Delayed Hypersensitivity
Minor Lymphocyte Stimulatory Loci
Color
Antigens

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

Multigenic regulation of the primary immune response to ovalbumin in mice. / Lubet, Martha Turner; Kettman, John R.

In: Immunogenetics, Vol. 9, No. 1, 12.1979, p. 45-55.

Research output: Contribution to journalArticle

Lubet, Martha Turner ; Kettman, John R. / Multigenic regulation of the primary immune response to ovalbumin in mice. In: Immunogenetics. 1979 ; Vol. 9, No. 1. pp. 45-55.
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