Multimodal Analysis of Cell Types in a Hypothalamic Node Controlling Social Behavior

Dong Wook Kim, Zizhen Yao, Lucas T. Graybuck, Tae Kyung Kim, Thuc Nghi Nguyen, Kimberly A. Smith, Olivia Fong, Lynn Yi, Noushin Koulena, Nico Pierson, Sheel Shah, Liching Lo, Allan Hermann Pool, Yuki Oka, Lior Pachter, Long Cai, Bosiljka Tasic, Hongkui Zeng, David J. Anderson

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Single-cell RNA sequencing of the mouse ventrolateral subdivision of the ventromedial hypothalamus, a brain region that contains ∼4,000 neurons and controls innate social behaviors including aggression and mounting, reveals several transcriptomic cell types that differ between males and females.

Original languageEnglish (US)
Pages (from-to)713-728.e17
JournalCell
Volume179
Issue number3
DOIs
StatePublished - Oct 17 2019
Externally publishedYes

Keywords

  • aggression
  • cell types
  • estrogen receptor
  • hypothalamus
  • mating
  • metabolism
  • sexual dimorphism
  • single-cell RNA sequencing
  • social behavior
  • VMH

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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