Multimodality Hyperpolarized C-13 MRS/PET/Multiparametric MR Imaging for Detection and Image-Guided Biopsy of Prostate Cancer: First Experience in a Canine Prostate Cancer Model

Sunitha V. Bachawal, Jae Mo Park, Keerthi S. Valluru, Mathias Dyrberg Loft, Stephen A. Felt, José G. Vilches-Moure, Yamil F. Saenz, Bruce Daniel, Andrei Iagaru, Geoffrey Sonn, Zhen Cheng, Daniel M. Spielman, Jürgen K. Willmann

Research output: Contribution to journalArticle

Abstract

Purpose: To assess whether simultaneous hyperpolarized C-13 magnetic resonance spectroscopy (MRS)/positron emission tomography (PET)/multiparametric magnetic resonance (mpMR) imaging is feasible in an orthotopic canine prostate cancer (PCa) model using a clinical PET/MR system and whether the combined imaging datasets can be fused with transrectal ultrasound (TRUS) in real time for multimodal image fusion-guided targeted biopsy of PCa. Procedures: Institutional Animal Care and Use Committee approval was obtained for this study. Canine prostate adenocarcinoma (Ace-1) cells were orthotopically injected into the prostate of four dogs. Once tumor engraftment was confirmed by TRUS, simultaneous hyperpolarized C-13 MRS of [1-13C]pyruvate, PET (2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), [68Ga]NODAGA-SCH1), and mpMR (T2W, DWI) imaging was performed using a clinical PET/MR system. Multimodality imaging data sets were then fused with TRUS and image-guided targeted biopsy was performed. Imaging results were then correlated with histological findings. Results: Successful tumor engraftment was histologically confirmed in three of the four dogs (dogs 2, 3, and 4) and simultaneous C-13 MRS/PET/mpMR was feasible in all three. In dog 2, C-13 MRS showed increased lactate signal in the tumor (lactate/totalC = 0.47) whereas mpMR did not show any signal changes. In dog 3, [18F]FDG-PET (SUVmean = 1.90) and C-13 MRS (lactate/totalC = 0.59) showed elevated metabolic activity in the tumor. In dog 4, [18F]FDG (SUVmean = 2.43), [68Ga]NODAGA-SCH1 (SUVmean = 0.75), and C-13 MRS (Lac/totalC = 0.53) showed elevated uptake in tumor compared to control tissue and multimodal image fusion-guided biopsy of the tumor was successfully performed. Conclusion: Simultaneous C-13 MRS/PET/mpMR imaging and multimodal image fusion-guided biopsy is feasible in a canine PCa model.

Original languageEnglish (US)
Pages (from-to)861-870
Number of pages10
JournalMolecular Imaging and Biology
Volume21
Issue number5
DOIs
StatePublished - Oct 1 2019

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Image-Guided Biopsy
Positron-Emission Tomography
Canidae
Prostatic Neoplasms
Magnetic Resonance Spectroscopy
Dogs
Fluorodeoxyglucose F18
Lactic Acid
Neoplasms
Prostate
Animal Care Committees
Magnetic Resonance Imaging
Pyruvic Acid
Adenocarcinoma

Keywords

  • Hyperpolarized MR spectroscopy
  • Image fusion
  • Multimodality imaging
  • Multiparametric MRI
  • PET
  • Prostate cancer
  • Targeted biopsy
  • Transrectal ultrasound

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Multimodality Hyperpolarized C-13 MRS/PET/Multiparametric MR Imaging for Detection and Image-Guided Biopsy of Prostate Cancer : First Experience in a Canine Prostate Cancer Model. / Bachawal, Sunitha V.; Park, Jae Mo; Valluru, Keerthi S.; Loft, Mathias Dyrberg; Felt, Stephen A.; Vilches-Moure, José G.; Saenz, Yamil F.; Daniel, Bruce; Iagaru, Andrei; Sonn, Geoffrey; Cheng, Zhen; Spielman, Daniel M.; Willmann, Jürgen K.

In: Molecular Imaging and Biology, Vol. 21, No. 5, 01.10.2019, p. 861-870.

Research output: Contribution to journalArticle

Bachawal, SV, Park, JM, Valluru, KS, Loft, MD, Felt, SA, Vilches-Moure, JG, Saenz, YF, Daniel, B, Iagaru, A, Sonn, G, Cheng, Z, Spielman, DM & Willmann, JK 2019, 'Multimodality Hyperpolarized C-13 MRS/PET/Multiparametric MR Imaging for Detection and Image-Guided Biopsy of Prostate Cancer: First Experience in a Canine Prostate Cancer Model', Molecular Imaging and Biology, vol. 21, no. 5, pp. 861-870. https://doi.org/10.1007/s11307-018-1235-6
Bachawal, Sunitha V. ; Park, Jae Mo ; Valluru, Keerthi S. ; Loft, Mathias Dyrberg ; Felt, Stephen A. ; Vilches-Moure, José G. ; Saenz, Yamil F. ; Daniel, Bruce ; Iagaru, Andrei ; Sonn, Geoffrey ; Cheng, Zhen ; Spielman, Daniel M. ; Willmann, Jürgen K. / Multimodality Hyperpolarized C-13 MRS/PET/Multiparametric MR Imaging for Detection and Image-Guided Biopsy of Prostate Cancer : First Experience in a Canine Prostate Cancer Model. In: Molecular Imaging and Biology. 2019 ; Vol. 21, No. 5. pp. 861-870.
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abstract = "Purpose: To assess whether simultaneous hyperpolarized C-13 magnetic resonance spectroscopy (MRS)/positron emission tomography (PET)/multiparametric magnetic resonance (mpMR) imaging is feasible in an orthotopic canine prostate cancer (PCa) model using a clinical PET/MR system and whether the combined imaging datasets can be fused with transrectal ultrasound (TRUS) in real time for multimodal image fusion-guided targeted biopsy of PCa. Procedures: Institutional Animal Care and Use Committee approval was obtained for this study. Canine prostate adenocarcinoma (Ace-1) cells were orthotopically injected into the prostate of four dogs. Once tumor engraftment was confirmed by TRUS, simultaneous hyperpolarized C-13 MRS of [1-13C]pyruvate, PET (2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), [68Ga]NODAGA-SCH1), and mpMR (T2W, DWI) imaging was performed using a clinical PET/MR system. Multimodality imaging data sets were then fused with TRUS and image-guided targeted biopsy was performed. Imaging results were then correlated with histological findings. Results: Successful tumor engraftment was histologically confirmed in three of the four dogs (dogs 2, 3, and 4) and simultaneous C-13 MRS/PET/mpMR was feasible in all three. In dog 2, C-13 MRS showed increased lactate signal in the tumor (lactate/totalC = 0.47) whereas mpMR did not show any signal changes. In dog 3, [18F]FDG-PET (SUVmean = 1.90) and C-13 MRS (lactate/totalC = 0.59) showed elevated metabolic activity in the tumor. In dog 4, [18F]FDG (SUVmean = 2.43), [68Ga]NODAGA-SCH1 (SUVmean = 0.75), and C-13 MRS (Lac/totalC = 0.53) showed elevated uptake in tumor compared to control tissue and multimodal image fusion-guided biopsy of the tumor was successfully performed. Conclusion: Simultaneous C-13 MRS/PET/mpMR imaging and multimodal image fusion-guided biopsy is feasible in a canine PCa model.",
keywords = "Hyperpolarized MR spectroscopy, Image fusion, Multimodality imaging, Multiparametric MRI, PET, Prostate cancer, Targeted biopsy, Transrectal ultrasound",
author = "Bachawal, {Sunitha V.} and Park, {Jae Mo} and Valluru, {Keerthi S.} and Loft, {Mathias Dyrberg} and Felt, {Stephen A.} and Vilches-Moure, {Jos{\'e} G.} and Saenz, {Yamil F.} and Bruce Daniel and Andrei Iagaru and Geoffrey Sonn and Zhen Cheng and Spielman, {Daniel M.} and Willmann, {J{\"u}rgen K.}",
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TY - JOUR

T1 - Multimodality Hyperpolarized C-13 MRS/PET/Multiparametric MR Imaging for Detection and Image-Guided Biopsy of Prostate Cancer

T2 - First Experience in a Canine Prostate Cancer Model

AU - Bachawal, Sunitha V.

AU - Park, Jae Mo

AU - Valluru, Keerthi S.

AU - Loft, Mathias Dyrberg

AU - Felt, Stephen A.

AU - Vilches-Moure, José G.

AU - Saenz, Yamil F.

AU - Daniel, Bruce

AU - Iagaru, Andrei

AU - Sonn, Geoffrey

AU - Cheng, Zhen

AU - Spielman, Daniel M.

AU - Willmann, Jürgen K.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Purpose: To assess whether simultaneous hyperpolarized C-13 magnetic resonance spectroscopy (MRS)/positron emission tomography (PET)/multiparametric magnetic resonance (mpMR) imaging is feasible in an orthotopic canine prostate cancer (PCa) model using a clinical PET/MR system and whether the combined imaging datasets can be fused with transrectal ultrasound (TRUS) in real time for multimodal image fusion-guided targeted biopsy of PCa. Procedures: Institutional Animal Care and Use Committee approval was obtained for this study. Canine prostate adenocarcinoma (Ace-1) cells were orthotopically injected into the prostate of four dogs. Once tumor engraftment was confirmed by TRUS, simultaneous hyperpolarized C-13 MRS of [1-13C]pyruvate, PET (2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), [68Ga]NODAGA-SCH1), and mpMR (T2W, DWI) imaging was performed using a clinical PET/MR system. Multimodality imaging data sets were then fused with TRUS and image-guided targeted biopsy was performed. Imaging results were then correlated with histological findings. Results: Successful tumor engraftment was histologically confirmed in three of the four dogs (dogs 2, 3, and 4) and simultaneous C-13 MRS/PET/mpMR was feasible in all three. In dog 2, C-13 MRS showed increased lactate signal in the tumor (lactate/totalC = 0.47) whereas mpMR did not show any signal changes. In dog 3, [18F]FDG-PET (SUVmean = 1.90) and C-13 MRS (lactate/totalC = 0.59) showed elevated metabolic activity in the tumor. In dog 4, [18F]FDG (SUVmean = 2.43), [68Ga]NODAGA-SCH1 (SUVmean = 0.75), and C-13 MRS (Lac/totalC = 0.53) showed elevated uptake in tumor compared to control tissue and multimodal image fusion-guided biopsy of the tumor was successfully performed. Conclusion: Simultaneous C-13 MRS/PET/mpMR imaging and multimodal image fusion-guided biopsy is feasible in a canine PCa model.

AB - Purpose: To assess whether simultaneous hyperpolarized C-13 magnetic resonance spectroscopy (MRS)/positron emission tomography (PET)/multiparametric magnetic resonance (mpMR) imaging is feasible in an orthotopic canine prostate cancer (PCa) model using a clinical PET/MR system and whether the combined imaging datasets can be fused with transrectal ultrasound (TRUS) in real time for multimodal image fusion-guided targeted biopsy of PCa. Procedures: Institutional Animal Care and Use Committee approval was obtained for this study. Canine prostate adenocarcinoma (Ace-1) cells were orthotopically injected into the prostate of four dogs. Once tumor engraftment was confirmed by TRUS, simultaneous hyperpolarized C-13 MRS of [1-13C]pyruvate, PET (2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG), [68Ga]NODAGA-SCH1), and mpMR (T2W, DWI) imaging was performed using a clinical PET/MR system. Multimodality imaging data sets were then fused with TRUS and image-guided targeted biopsy was performed. Imaging results were then correlated with histological findings. Results: Successful tumor engraftment was histologically confirmed in three of the four dogs (dogs 2, 3, and 4) and simultaneous C-13 MRS/PET/mpMR was feasible in all three. In dog 2, C-13 MRS showed increased lactate signal in the tumor (lactate/totalC = 0.47) whereas mpMR did not show any signal changes. In dog 3, [18F]FDG-PET (SUVmean = 1.90) and C-13 MRS (lactate/totalC = 0.59) showed elevated metabolic activity in the tumor. In dog 4, [18F]FDG (SUVmean = 2.43), [68Ga]NODAGA-SCH1 (SUVmean = 0.75), and C-13 MRS (Lac/totalC = 0.53) showed elevated uptake in tumor compared to control tissue and multimodal image fusion-guided biopsy of the tumor was successfully performed. Conclusion: Simultaneous C-13 MRS/PET/mpMR imaging and multimodal image fusion-guided biopsy is feasible in a canine PCa model.

KW - Hyperpolarized MR spectroscopy

KW - Image fusion

KW - Multimodality imaging

KW - Multiparametric MRI

KW - PET

KW - Prostate cancer

KW - Targeted biopsy

KW - Transrectal ultrasound

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