Multiple immunoreactive inhibin proteins in serum from postmenopausal women with epithelial ovarian cancer

G. M. Lambert-Messerlian, M. Steinhoff, W. Zheng, J. A. Canick, W. H. Gajewski, D. B. Seifer, A. L. Schneyer

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Abstract

Inhibin is an ovarian protein previously shown, using a nonspecific assay, to be elevated in serum of women with ovarian cancer. However, inhibin is secreted in multiple biochemical forms, including dimeric inhibin A and B and α inhibin precursors (pro-αC), each of which can now be specifically measured. We have examined the secretion of inhibin B and pro-αC inhibin in serum from women with epithelial ovarian cancer (EOC) for the first time, and have compared these analytes to inhibin A and total inhibin (inhibin A + B + pro-αC) as potential serum markers for EOC in postmenopausal women. Of all the immunoreactive inhibin proteins studied, the best serum marker was pro- αC, with 22% of women with EOC having levels that exceeded the range of values in women without EOC. Since CA 125 and pro-αC levels were not significantly correlated, combination of these markers resulted in 87% of EOC cases having elevated preoperative serum levels, a 9% increase over CA 125 alone. These data suggest that α inhibin secretion, especially pro-αC, may be useful in addition to CA 125 as a serum marker for EOC in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)512-516
Number of pages5
JournalGynecologic oncology
Volume65
Issue number3
DOIs
StatePublished - Jun 1997

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ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Cite this

Lambert-Messerlian, G. M., Steinhoff, M., Zheng, W., Canick, J. A., Gajewski, W. H., Seifer, D. B., & Schneyer, A. L. (1997). Multiple immunoreactive inhibin proteins in serum from postmenopausal women with epithelial ovarian cancer. Gynecologic oncology, 65(3), 512-516. https://doi.org/10.1006/gyno.1997.4719