Multiple immunoreactive inhibin proteins in serum from postmenopausal women with epithelial ovarian cancer

G. M. Lambert-Messerlian, M. Steinhoff, W. Zheng, J. A. Canick, W. H. Gajewski, D. B. Seifer, A. L. Schneyer

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Inhibin is an ovarian protein previously shown, using a nonspecific assay, to be elevated in serum of women with ovarian cancer. However, inhibin is secreted in multiple biochemical forms, including dimeric inhibin A and B and α inhibin precursors (pro-αC), each of which can now be specifically measured. We have examined the secretion of inhibin B and pro-αC inhibin in serum from women with epithelial ovarian cancer (EOC) for the first time, and have compared these analytes to inhibin A and total inhibin (inhibin A + B + pro-αC) as potential serum markers for EOC in postmenopausal women. Of all the immunoreactive inhibin proteins studied, the best serum marker was pro- αC, with 22% of women with EOC having levels that exceeded the range of values in women without EOC. Since CA 125 and pro-αC levels were not significantly correlated, combination of these markers resulted in 87% of EOC cases having elevated preoperative serum levels, a 9% increase over CA 125 alone. These data suggest that α inhibin secretion, especially pro-αC, may be useful in addition to CA 125 as a serum marker for EOC in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)512-516
Number of pages5
JournalGynecologic Oncology
Volume65
Issue number3
DOIs
StatePublished - Jan 1 1997

Fingerprint

Inhibins
Blood Proteins
Biomarkers
Serum
Ovarian epithelial cancer
Ovarian Neoplasms
Proteins
inhibin A
inhibin B

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

Cite this

Lambert-Messerlian, G. M., Steinhoff, M., Zheng, W., Canick, J. A., Gajewski, W. H., Seifer, D. B., & Schneyer, A. L. (1997). Multiple immunoreactive inhibin proteins in serum from postmenopausal women with epithelial ovarian cancer. Gynecologic Oncology, 65(3), 512-516. https://doi.org/10.1006/gyno.1997.4719

Multiple immunoreactive inhibin proteins in serum from postmenopausal women with epithelial ovarian cancer. / Lambert-Messerlian, G. M.; Steinhoff, M.; Zheng, W.; Canick, J. A.; Gajewski, W. H.; Seifer, D. B.; Schneyer, A. L.

In: Gynecologic Oncology, Vol. 65, No. 3, 01.01.1997, p. 512-516.

Research output: Contribution to journalArticle

Lambert-Messerlian, GM, Steinhoff, M, Zheng, W, Canick, JA, Gajewski, WH, Seifer, DB & Schneyer, AL 1997, 'Multiple immunoreactive inhibin proteins in serum from postmenopausal women with epithelial ovarian cancer', Gynecologic Oncology, vol. 65, no. 3, pp. 512-516. https://doi.org/10.1006/gyno.1997.4719
Lambert-Messerlian, G. M. ; Steinhoff, M. ; Zheng, W. ; Canick, J. A. ; Gajewski, W. H. ; Seifer, D. B. ; Schneyer, A. L. / Multiple immunoreactive inhibin proteins in serum from postmenopausal women with epithelial ovarian cancer. In: Gynecologic Oncology. 1997 ; Vol. 65, No. 3. pp. 512-516.
@article{a690b59d6bbd4d97a291683a4d5495dc,
title = "Multiple immunoreactive inhibin proteins in serum from postmenopausal women with epithelial ovarian cancer",
abstract = "Inhibin is an ovarian protein previously shown, using a nonspecific assay, to be elevated in serum of women with ovarian cancer. However, inhibin is secreted in multiple biochemical forms, including dimeric inhibin A and B and α inhibin precursors (pro-αC), each of which can now be specifically measured. We have examined the secretion of inhibin B and pro-αC inhibin in serum from women with epithelial ovarian cancer (EOC) for the first time, and have compared these analytes to inhibin A and total inhibin (inhibin A + B + pro-αC) as potential serum markers for EOC in postmenopausal women. Of all the immunoreactive inhibin proteins studied, the best serum marker was pro- αC, with 22{\%} of women with EOC having levels that exceeded the range of values in women without EOC. Since CA 125 and pro-αC levels were not significantly correlated, combination of these markers resulted in 87{\%} of EOC cases having elevated preoperative serum levels, a 9{\%} increase over CA 125 alone. These data suggest that α inhibin secretion, especially pro-αC, may be useful in addition to CA 125 as a serum marker for EOC in postmenopausal women.",
author = "Lambert-Messerlian, {G. M.} and M. Steinhoff and W. Zheng and Canick, {J. A.} and Gajewski, {W. H.} and Seifer, {D. B.} and Schneyer, {A. L.}",
year = "1997",
month = "1",
day = "1",
doi = "10.1006/gyno.1997.4719",
language = "English (US)",
volume = "65",
pages = "512--516",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "3",

}

TY - JOUR

T1 - Multiple immunoreactive inhibin proteins in serum from postmenopausal women with epithelial ovarian cancer

AU - Lambert-Messerlian, G. M.

AU - Steinhoff, M.

AU - Zheng, W.

AU - Canick, J. A.

AU - Gajewski, W. H.

AU - Seifer, D. B.

AU - Schneyer, A. L.

PY - 1997/1/1

Y1 - 1997/1/1

N2 - Inhibin is an ovarian protein previously shown, using a nonspecific assay, to be elevated in serum of women with ovarian cancer. However, inhibin is secreted in multiple biochemical forms, including dimeric inhibin A and B and α inhibin precursors (pro-αC), each of which can now be specifically measured. We have examined the secretion of inhibin B and pro-αC inhibin in serum from women with epithelial ovarian cancer (EOC) for the first time, and have compared these analytes to inhibin A and total inhibin (inhibin A + B + pro-αC) as potential serum markers for EOC in postmenopausal women. Of all the immunoreactive inhibin proteins studied, the best serum marker was pro- αC, with 22% of women with EOC having levels that exceeded the range of values in women without EOC. Since CA 125 and pro-αC levels were not significantly correlated, combination of these markers resulted in 87% of EOC cases having elevated preoperative serum levels, a 9% increase over CA 125 alone. These data suggest that α inhibin secretion, especially pro-αC, may be useful in addition to CA 125 as a serum marker for EOC in postmenopausal women.

AB - Inhibin is an ovarian protein previously shown, using a nonspecific assay, to be elevated in serum of women with ovarian cancer. However, inhibin is secreted in multiple biochemical forms, including dimeric inhibin A and B and α inhibin precursors (pro-αC), each of which can now be specifically measured. We have examined the secretion of inhibin B and pro-αC inhibin in serum from women with epithelial ovarian cancer (EOC) for the first time, and have compared these analytes to inhibin A and total inhibin (inhibin A + B + pro-αC) as potential serum markers for EOC in postmenopausal women. Of all the immunoreactive inhibin proteins studied, the best serum marker was pro- αC, with 22% of women with EOC having levels that exceeded the range of values in women without EOC. Since CA 125 and pro-αC levels were not significantly correlated, combination of these markers resulted in 87% of EOC cases having elevated preoperative serum levels, a 9% increase over CA 125 alone. These data suggest that α inhibin secretion, especially pro-αC, may be useful in addition to CA 125 as a serum marker for EOC in postmenopausal women.

UR - http://www.scopus.com/inward/record.url?scp=0031172116&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031172116&partnerID=8YFLogxK

U2 - 10.1006/gyno.1997.4719

DO - 10.1006/gyno.1997.4719

M3 - Article

C2 - 9190984

AN - SCOPUS:0031172116

VL - 65

SP - 512

EP - 516

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 3

ER -