Multiple sclerosis and chronic cerebrospinal venous insufficiency: A critical review

Amer M. Awad, Ellen Marder, Ron Milo, Olaf Stüve

Research output: Contribution to journalArticle

5 Scopus citations


Chronic cerebrospinal venous insufficiency (CCSVI) was recently proposed as a contributing factor in the pathology of multiple sclerosis. This concept has gained remarkable attention, partly because endovascular neurointervention has been suggested as a treatment strategy. This review summarizes available evidence and provides a critical analysis of the published data. Currently, there is inconclusive evidence to support CCSVI as an etiological factor in patients with multiple sclerosis. Endovascular procedures should not be undertaken outside of controlled clinical trials.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalTherapeutic Advances in Neurological Disorders
Issue number4
Publication statusPublished - Jul 2011



  • chronic cerebrospinal venous insufficiency
  • multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Pharmacology

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