Multiple sclerosis flares associated with recombinant granulocyte colony-stimulating factor

H. Openshaw, O. Stuve, J. P. Antel, R. Nash, B. T. Lund, L. P. Weiner, A. Kashyap, P. McSweeney, S. Forman

Research output: Contribution to journalArticle

127 Scopus citations

Abstract

Four of 10 patients who were enrolled on protocols of high-dose immunosuppression with peripheral blood stem cell rescue for MS experienced neurologic worsening while receiving recombinant human granulocyte colony- stimulating factor. There was improvement when methylprednisolone was given to three of the patients, but one patient died of respiratory failure. The mechanism of the neurologic worsening is uncertain.

Original languageEnglish (US)
Pages (from-to)2147-2150
Number of pages4
JournalNeurology
Volume54
Issue number11
DOIs
StatePublished - Jun 13 2000

Keywords

  • Granulocyte colony-stimulating factor
  • Immunosuppression
  • MS
  • Stem cell transplantation

ASJC Scopus subject areas

  • Clinical Neurology

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  • Cite this

    Openshaw, H., Stuve, O., Antel, J. P., Nash, R., Lund, B. T., Weiner, L. P., Kashyap, A., McSweeney, P., & Forman, S. (2000). Multiple sclerosis flares associated with recombinant granulocyte colony-stimulating factor. Neurology, 54(11), 2147-2150. https://doi.org/10.1212/WNL.54.11.2147