TY - JOUR
T1 - Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression
T2 - More complicated than we thought
AU - Stocco, Douglas M.
AU - Wang, XingJia
AU - Jo, Youngah
AU - Manna, Pulak R.
PY - 2005/11
Y1 - 2005/11
N2 - Steroid hormone biosynthesis in steroidogenic cells is regulated through trophic hormone activation of protein kinase A (PKA) signaling pathways. However, many examples of the regulation of steroid synthesis via pathways other than the PKA pathway have been documented. In some cases these pathways act independently of PKA activation whereas in other cases, they act synergistically with it. The current understanding of additional signaling pathways and factors, such as the protein kinase C pathway, arachidonic acid metabolites, growth factors, chloride ion, the calcium messenger system, and others capable of regulating/modulating steroid hormone biosynthesis, and in many cases steroidogenic acute regulatory protein expression, are discussed in this review.
AB - Steroid hormone biosynthesis in steroidogenic cells is regulated through trophic hormone activation of protein kinase A (PKA) signaling pathways. However, many examples of the regulation of steroid synthesis via pathways other than the PKA pathway have been documented. In some cases these pathways act independently of PKA activation whereas in other cases, they act synergistically with it. The current understanding of additional signaling pathways and factors, such as the protein kinase C pathway, arachidonic acid metabolites, growth factors, chloride ion, the calcium messenger system, and others capable of regulating/modulating steroid hormone biosynthesis, and in many cases steroidogenic acute regulatory protein expression, are discussed in this review.
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U2 - 10.1210/me.2004-0532
DO - 10.1210/me.2004-0532
M3 - Short survey
C2 - 15831519
AN - SCOPUS:27644505023
SN - 0888-8809
VL - 19
SP - 2647
EP - 2659
JO - Molecular Endocrinology
JF - Molecular Endocrinology
IS - 11
ER -