Multiple voltage-dependent mechanisms potentiate calcium channel activity in hippocampal neurons

Ege T. Kavalali, Mark R. Plummer

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Neuronal voltage-gated calcium channels provide a pathway for calcium influx that is required for processes ranging from intracellular signaling to alterations in cellular excitability. In hippocampal neurons, we have characterized a subtype of dihydropyridine-sensitive L-type calcium channels (Lp channel) that shows multiple kinds of voltage-dependent potentiation of its activity. One type of potentiation is elicited by low-voltage stimuli (- 10 mV) and can be seen in dual-pulse protocols in which a transient hyperpolarization is interposed between conditioning and test pulses. The second type of potentiation is elicited by much higher voltages (+60 mV) and is selectively deactivated at hyperpolarized voltages. We have compared these types of potentiation in the Lp channel, the 'standard' L-type channel, and the cardiac L-type channel. Our results show that the high-voltage potentiation is common to all three channel types. The low-voltage form of potentiation, however, is unique to the Lp channel. Thus, the Lp channel shows two kinds of potentiation that differ in their voltage dependence and rate of decay. Therefore, calcium channel plasticity in the hippocampus has a variety of forms distinguished by their stimulus requirements and duration.

Original languageEnglish (US)
Pages (from-to)1072-1082
Number of pages11
JournalJournal of Neuroscience
Volume16
Issue number3
StatePublished - Feb 1 1996

Fingerprint

L-Type Calcium Channels
Calcium Channels
Neurons
Hippocampus
Calcium

Keywords

  • calcium
  • calcium channel
  • dihydropyridine
  • facilitation
  • hippocampus
  • plasticity
  • potentiation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Multiple voltage-dependent mechanisms potentiate calcium channel activity in hippocampal neurons. / Kavalali, Ege T.; Plummer, Mark R.

In: Journal of Neuroscience, Vol. 16, No. 3, 01.02.1996, p. 1072-1082.

Research output: Contribution to journalArticle

Kavalali, Ege T. ; Plummer, Mark R. / Multiple voltage-dependent mechanisms potentiate calcium channel activity in hippocampal neurons. In: Journal of Neuroscience. 1996 ; Vol. 16, No. 3. pp. 1072-1082.
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