Multiplex inheritance of component phenotypes in a murine model of lupus

Laurence Morel, Chandra Mohan, Ying Yu, Joel Schiffenbauer, Ulrich H. Rudofsky, Nana Tian, Jeff A. Longmate, Edward K. Wakeland

Research output: Contribution to journalArticle

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Abstract

We analyzed the linkage of GN and a wide spectrum of serological phenotypes associated with systemic lupus erythematosus in a (NZM2410 x C57BL/6)F2 cross. Some phenotypes, such as glomerulonephritis (GN) and anti- chromatin IgG antibody production, were more penetrant in females, but others, such as anti-dsDNA antibody production, did not show a gender bias. These results suggest that gender bias affects only a subset of SLE-component phenotypes, and that NZM2410 can be used to dissect the genetic basis of this phenomenon. Genome scanning linked six chromosomal intervals with the expression of one or more component phenotypes. These loci included two Sle loci previously identified in an (NZM2410 x B6)F1 x NZM2410 backcross, loci identified by others in the NZB/W model. Our analysis also suggested two new intervals on chromosomes (Chrs.) 10 and 11. Detailed analysis of the segregation of different phenotypes within these intervals suggests that they encompass more than one susceptibility locus. This clustering has been a common finding in several murine polygenic traits. Each of NZM2410 susceptibility loci can be aligned with a specific genetic pathways contributing to SLE pathogenesis on the basis of the spectrum of component phenotypes expressed.

Original languageEnglish (US)
Pages (from-to)176-181
Number of pages6
JournalMammalian Genome
Volume10
Issue number2
DOIs
StatePublished - 1999

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Phenotype
Sexism
Glomerulonephritis
Antibody Formation
Genetic Phenomena
Multifactorial Inheritance
Chromosomes, Human, Pair 10
Chromosomes, Human, Pair 11
Systemic Lupus Erythematosus
Chromatin
Cluster Analysis
Anti-Idiotypic Antibodies
Genome

ASJC Scopus subject areas

  • Genetics

Cite this

Morel, L., Mohan, C., Yu, Y., Schiffenbauer, J., Rudofsky, U. H., Tian, N., ... Wakeland, E. K. (1999). Multiplex inheritance of component phenotypes in a murine model of lupus. Mammalian Genome, 10(2), 176-181. https://doi.org/10.1007/s003359900964

Multiplex inheritance of component phenotypes in a murine model of lupus. / Morel, Laurence; Mohan, Chandra; Yu, Ying; Schiffenbauer, Joel; Rudofsky, Ulrich H.; Tian, Nana; Longmate, Jeff A.; Wakeland, Edward K.

In: Mammalian Genome, Vol. 10, No. 2, 1999, p. 176-181.

Research output: Contribution to journalArticle

Morel, L, Mohan, C, Yu, Y, Schiffenbauer, J, Rudofsky, UH, Tian, N, Longmate, JA & Wakeland, EK 1999, 'Multiplex inheritance of component phenotypes in a murine model of lupus', Mammalian Genome, vol. 10, no. 2, pp. 176-181. https://doi.org/10.1007/s003359900964
Morel L, Mohan C, Yu Y, Schiffenbauer J, Rudofsky UH, Tian N et al. Multiplex inheritance of component phenotypes in a murine model of lupus. Mammalian Genome. 1999;10(2):176-181. https://doi.org/10.1007/s003359900964
Morel, Laurence ; Mohan, Chandra ; Yu, Ying ; Schiffenbauer, Joel ; Rudofsky, Ulrich H. ; Tian, Nana ; Longmate, Jeff A. ; Wakeland, Edward K. / Multiplex inheritance of component phenotypes in a murine model of lupus. In: Mammalian Genome. 1999 ; Vol. 10, No. 2. pp. 176-181.
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