Multiplexed dendritic targeting of α calcium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associated protein RNAs by the A2 pathway

Yuanzheng Gao, Vedakumar Tatavarty, George Korza, Mikhail K. Levin, John H. Carson

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

In neurons, many different RNAs are targeted to dendrites where local expression of the encoded proteins mediates synaptic plasticity during learning and memory. It is not known whether each RNA follows a separate trafficking pathway or whether multiple RNAs are targeted to dendrites by the same pathway. Here, we show that RNAs encoding α calcium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associated protein are coassembled into the same RNA granules and targeted to dendrites by the same cis/trans-determinants (heterogeneous nuclear ribonucleoprotein [hnRNP] A2 response element and hnRNP A2) that mediate dendritic targeting of myelin basic protein RNA by the A2 pathway in oligodendrocytes. Multiplexed dendritic targeting of different RNAs by the same pathway represents a new organizing principle for coordinating gene expression at the synapse.

Original languageEnglish (US)
Pages (from-to)2311-2327
Number of pages17
JournalMolecular Biology of the Cell
Volume19
Issue number5
DOIs
StatePublished - May 2008

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Neurogranin
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases
Cytoskeleton
varespladib methyl
RNA
Dendrites
Proteins
Heterogeneous-Nuclear Ribonucleoproteins
Neuronal Plasticity
Myelin Basic Protein
Oligodendroglia
Response Elements
Synapses
Learning
Gene Expression
Neurons

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Multiplexed dendritic targeting of α calcium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associated protein RNAs by the A2 pathway. / Gao, Yuanzheng; Tatavarty, Vedakumar; Korza, George; Levin, Mikhail K.; Carson, John H.

In: Molecular Biology of the Cell, Vol. 19, No. 5, 05.2008, p. 2311-2327.

Research output: Contribution to journalArticle

Gao, Yuanzheng ; Tatavarty, Vedakumar ; Korza, George ; Levin, Mikhail K. ; Carson, John H. / Multiplexed dendritic targeting of α calcium calmodulin-dependent protein kinase II, neurogranin, and activity-regulated cytoskeleton-associated protein RNAs by the A2 pathway. In: Molecular Biology of the Cell. 2008 ; Vol. 19, No. 5. pp. 2311-2327.
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