Multiplexed RNA trafficking in oligodendrocytes and neurons

John H. Carson; Yuanzheng Gao; Vedakumar Tatavarty; Mikhail K. Levin; George Korza; Victor P. Francone; Linda D. Kosturko; Michael J. Maggipinto; Elisa Barbarese

doi:10.1016/j.bbagrm.2008.04.002

Multiplexed RNA trafficking in oligodendrocytes and neurons

John H. Carson, Yuanzheng Gao, Vedakumar Tatavarty, Mikhail K. Levin, George Korza, Victor P. Francone, Linda D. Kosturko, Michael J. Maggipinto, Elisa Barbarese

Clinical Sciences

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Abstract

In oligodendrocytes and neurons genetic information is transmitted from the nucleus to dendrites in the form of RNA granules. Here we describe how transport of multiple different RNA molecules in individual granules is analogous to the process of multiplexing in telecommunications. In both cases multiple messages are combined into a composite signal for transmission on a single carrier. Multiplexing provides a mechanism to coordinate local expression of ensembles of genes in myelin in oligodendrocytes and at synapses in neurons.

Original language	English (US)
Pages (from-to)	453-458
Number of pages	6
Journal	Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume	1779
Issue number	8
DOIs	https://doi.org/10.1016/j.bbagrm.2008.04.002
State	Published - Aug 2008

Keywords

HnRNP A2
Myelin
RNA granule
Synapse
TOG

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics

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10.1016/j.bbagrm.2008.04.002

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title = "Multiplexed RNA trafficking in oligodendrocytes and neurons",

abstract = "In oligodendrocytes and neurons genetic information is transmitted from the nucleus to dendrites in the form of RNA granules. Here we describe how transport of multiple different RNA molecules in individual granules is analogous to the process of multiplexing in telecommunications. In both cases multiple messages are combined into a composite signal for transmission on a single carrier. Multiplexing provides a mechanism to coordinate local expression of ensembles of genes in myelin in oligodendrocytes and at synapses in neurons.",

keywords = "HnRNP A2, Myelin, RNA granule, Synapse, TOG",

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T1 - Multiplexed RNA trafficking in oligodendrocytes and neurons

AU - Carson, John H.

AU - Gao, Yuanzheng

AU - Tatavarty, Vedakumar

AU - Levin, Mikhail K.

AU - Korza, George

AU - Francone, Victor P.

AU - Kosturko, Linda D.

AU - Maggipinto, Michael J.

AU - Barbarese, Elisa

PY - 2008/8

Y1 - 2008/8

N2 - In oligodendrocytes and neurons genetic information is transmitted from the nucleus to dendrites in the form of RNA granules. Here we describe how transport of multiple different RNA molecules in individual granules is analogous to the process of multiplexing in telecommunications. In both cases multiple messages are combined into a composite signal for transmission on a single carrier. Multiplexing provides a mechanism to coordinate local expression of ensembles of genes in myelin in oligodendrocytes and at synapses in neurons.

AB - In oligodendrocytes and neurons genetic information is transmitted from the nucleus to dendrites in the form of RNA granules. Here we describe how transport of multiple different RNA molecules in individual granules is analogous to the process of multiplexing in telecommunications. In both cases multiple messages are combined into a composite signal for transmission on a single carrier. Multiplexing provides a mechanism to coordinate local expression of ensembles of genes in myelin in oligodendrocytes and at synapses in neurons.

KW - HnRNP A2

KW - Myelin

KW - RNA granule

KW - Synapse

KW - TOG

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DO - 10.1016/j.bbagrm.2008.04.002

M3 - Review article

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AN - SCOPUS:49549123825

SN - 1874-9399

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JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

IS - 8

ER -

Multiplexed RNA trafficking in oligodendrocytes and neurons

Abstract

Keywords

ASJC Scopus subject areas

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