Multiplexed RNA trafficking in oligodendrocytes and neurons

John H. Carson, Yuanzheng Gao, Vedakumar Tatavarty, Mikhail K. Levin, George Korza, Victor P. Francone, Linda D. Kosturko, Michael J. Maggipinto, Elisa Barbarese

Research output: Contribution to journalReview article

38 Scopus citations

Abstract

In oligodendrocytes and neurons genetic information is transmitted from the nucleus to dendrites in the form of RNA granules. Here we describe how transport of multiple different RNA molecules in individual granules is analogous to the process of multiplexing in telecommunications. In both cases multiple messages are combined into a composite signal for transmission on a single carrier. Multiplexing provides a mechanism to coordinate local expression of ensembles of genes in myelin in oligodendrocytes and at synapses in neurons.

Original languageEnglish (US)
Pages (from-to)453-458
Number of pages6
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume1779
Issue number8
DOIs
StatePublished - Aug 1 2008

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Keywords

  • HnRNP A2
  • Myelin
  • RNA granule
  • Synapse
  • TOG

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Carson, J. H., Gao, Y., Tatavarty, V., Levin, M. K., Korza, G., Francone, V. P., Kosturko, L. D., Maggipinto, M. J., & Barbarese, E. (2008). Multiplexed RNA trafficking in oligodendrocytes and neurons. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms, 1779(8), 453-458. https://doi.org/10.1016/j.bbagrm.2008.04.002