Multivoxel MR spectroscopy in acute ischemic stroke

Comparison to the stroke protocol MRI

Krishna A. Dani, Li An, Erica C. Henning, Jun Shen, Steven Warach

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background and Purpose-Few patients with stroke have been imaged with MR spectroscopy (MRS) within the first few hours after onset. We compared data from current MRI protocols to MRS in subjects with ischemic stroke. Methods-MRS was incorporated into the standard clinical MRI stroke protocol for subjects <24 hours after onset. MRI and clinical correlates for the metabolic data from MRS were sought. Results-One hundred thirty-six MRS voxels from 32 subjects were analyzed. Lactate preceded the appearance of the lesion on diffusion-weighted imaging in some voxels but in others lagged behind it. Current protocols may predict up to 41% of the variance of MRS metabolites. Serum glucose concentration and time to maximum partially predicted the concentration of all major metabolites. Conclusion-MRS may be helpful in acute stroke, especially for lactate detection when perfusion-weighted imaging is unavailable. Current MRI protocols do provide surrogate markers for some indices of metabolic activity.

Original languageEnglish (US)
Pages (from-to)2962-2967
Number of pages6
JournalStroke
Volume43
Issue number11
DOIs
StatePublished - Nov 2012

Fingerprint

Magnetic Resonance Spectroscopy
Stroke
Lactic Acid
Perfusion Imaging
Biomarkers
Glucose
Serum

Keywords

  • magnetic resonance spectroscopy
  • spectroscopy
  • stroke

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Advanced and Specialized Nursing

Cite this

Multivoxel MR spectroscopy in acute ischemic stroke : Comparison to the stroke protocol MRI. / Dani, Krishna A.; An, Li; Henning, Erica C.; Shen, Jun; Warach, Steven.

In: Stroke, Vol. 43, No. 11, 11.2012, p. 2962-2967.

Research output: Contribution to journalArticle

Dani, KA, An, L, Henning, EC, Shen, J & Warach, S 2012, 'Multivoxel MR spectroscopy in acute ischemic stroke: Comparison to the stroke protocol MRI', Stroke, vol. 43, no. 11, pp. 2962-2967. https://doi.org/10.1161/STROKEAHA.112.656058
Dani, Krishna A. ; An, Li ; Henning, Erica C. ; Shen, Jun ; Warach, Steven. / Multivoxel MR spectroscopy in acute ischemic stroke : Comparison to the stroke protocol MRI. In: Stroke. 2012 ; Vol. 43, No. 11. pp. 2962-2967.
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