Muramyl dipeptide-induced changes in murine splenocyte responses to concanavalin A

Igor M. Dozmorov, Lyudmila V. Bagaeva, Igor I. Kuzin, Alexander M. Sapozhnikov, Elena V. Svirshchevskaya, Tatyana M. Andronova, Rem V. Petrov

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5 Scopus citations

Abstract

The effect of muramyl dipeptide (MDP) on Con A-stimulated activation of murine spleen cells was studied. MDP was found to enhance or suppress the proliferative response of splenocytes when different concentrations of Con A were used. MDP was shown to change the IL-2 content in culture supernatants of stimulated cells and to influence IL-2-dependent proliferation of Con A-blasts. A high degree of correlation was found between the proliferation of Con A-blasts and the expression of IL-2 receptors on Con A-blasts. This correlation, however, disappeared in the presence of MDP. The effects of MDP were shown to depend on the level of initial cell activity or rather on conditions leading to a given initial activity of cells.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalInternational Journal of Immunopharmacology
Volume14
Issue number2
DOIs
StatePublished - Feb 1992

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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    Dozmorov, I. M., Bagaeva, L. V., Kuzin, I. I., Sapozhnikov, A. M., Svirshchevskaya, E. V., Andronova, T. M., & Petrov, R. V. (1992). Muramyl dipeptide-induced changes in murine splenocyte responses to concanavalin A. International Journal of Immunopharmacology, 14(2), 159-165. https://doi.org/10.1016/0192-0561(92)90026-H