Murine progressive ankylosis is not immunologically mediated

Hollis E. Krug, Monica M. Wietgrefe, Steven R. Ytterberg, Joel D. Taurog, Maren L. Mahowald

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective. Murine progressive ankylosis is an autosomal recessive disorder in mice similar to the human spondyloarthropathies. The gene responsible for progressive ankylosis, ank, has not been identified and its product is unknown. We investigated whether the immune system plays a role in the pathogenesis of progressive ankylosis. Methods. Reciprocal transfers of spleen or bone marrow cells or serum between ank/ank and normal mice were performed. CD4 T cells were depleted in vivo by injection with monoclonal antibody. Ank/ank; nu/nu mice were bred from double heterozygote offspring of homozygote parents. Results. Disease was neither ameliorated nor induced by these immune system manipulations. Conclusion. We conclude that progressive ankylosis is not immune mediated. The similarities between ankylosing spondylitis and murine progressive ankylosis may be due to mechanisms producing osteogenesis in nonosseous tissues.

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalJournal of Rheumatology
Volume24
Issue number1
StatePublished - Jan 1997

Fingerprint

Ankylosis
Immune System
Spondylarthropathies
Ankylosing Spondylitis
Homozygote
Heterozygote
Osteogenesis
Bone Marrow Cells
Spleen
Monoclonal Antibodies
T-Lymphocytes
Injections
Serum
Genes

Keywords

  • animal disease models
  • mice
  • spondyloarthropathies

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Krug, H. E., Wietgrefe, M. M., Ytterberg, S. R., Taurog, J. D., & Mahowald, M. L. (1997). Murine progressive ankylosis is not immunologically mediated. Journal of Rheumatology, 24(1), 115-122.

Murine progressive ankylosis is not immunologically mediated. / Krug, Hollis E.; Wietgrefe, Monica M.; Ytterberg, Steven R.; Taurog, Joel D.; Mahowald, Maren L.

In: Journal of Rheumatology, Vol. 24, No. 1, 01.1997, p. 115-122.

Research output: Contribution to journalArticle

Krug, HE, Wietgrefe, MM, Ytterberg, SR, Taurog, JD & Mahowald, ML 1997, 'Murine progressive ankylosis is not immunologically mediated', Journal of Rheumatology, vol. 24, no. 1, pp. 115-122.
Krug HE, Wietgrefe MM, Ytterberg SR, Taurog JD, Mahowald ML. Murine progressive ankylosis is not immunologically mediated. Journal of Rheumatology. 1997 Jan;24(1):115-122.
Krug, Hollis E. ; Wietgrefe, Monica M. ; Ytterberg, Steven R. ; Taurog, Joel D. ; Mahowald, Maren L. / Murine progressive ankylosis is not immunologically mediated. In: Journal of Rheumatology. 1997 ; Vol. 24, No. 1. pp. 115-122.
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