Musashi1: An RBP with versatile functions in normal and cancer stem cells

Robert I. Glazer, Dat T. Vo, Luiz O.F. Penalva

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Musashi1 (Msi1) is a highly conserved RNA binding protein that was initially identified in Drosophila by its ability to regulate sensory organ development and asymmetric cell division. Studies in mammalian cells reveal multiple functions for Musashi1 in normal and abnormal processes by mediating different posttranscriptional processes. According to our recent studies, Musashi1 very likely controls hundreds of targets, forming networks that regulate apoptosis, differentiation, proliferation and cell cycle. Musashi1 is a characteristic stem cell marker that regulates the balance between selfrenewal and differentiation. Over-expression of Musashi1 has been associated with numerous tumor types and its function is required for tumor growth in breast, colon, medulloblastoma and glioblastoma. Musashi1 has also been implicated in neurogenesis and neurodegenerative diseases, and is emerging as a potential therapeutic target in both regenerative medicine and cancer.

Original languageEnglish (US)
Pages (from-to)54-64
Number of pages11
JournalFrontiers in Bioscience
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

Fingerprint

Neoplastic Stem Cells
Stem cells
Cells
Tumors
Asymmetric Cell Division
Neurodegenerative diseases
Neoplasms
Medulloblastoma
Regenerative Medicine
RNA-Binding Proteins
Neurogenesis
Glioblastoma
Neurodegenerative Diseases
Drosophila
Cell Cycle
Colon
Breast
Stem Cells
Apoptosis
Growth

Keywords

  • Cancer
  • Cancer Stem Cell
  • Musashi1
  • Nervous System Development
  • Neurological Disease
  • Post-Transcriptional Gene Regulation
  • Review
  • Ribonomics
  • RNA-Binding Protein
  • Splicing
  • Stem Cell
  • Translational Regulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Musashi1 : An RBP with versatile functions in normal and cancer stem cells. / Glazer, Robert I.; Vo, Dat T.; Penalva, Luiz O.F.

In: Frontiers in Bioscience, Vol. 17, No. 1, 01.01.2012, p. 54-64.

Research output: Contribution to journalArticle

Glazer, Robert I. ; Vo, Dat T. ; Penalva, Luiz O.F. / Musashi1 : An RBP with versatile functions in normal and cancer stem cells. In: Frontiers in Bioscience. 2012 ; Vol. 17, No. 1. pp. 54-64.
@article{1f0be39fae6e426eb29871a5dc39cca0,
title = "Musashi1: An RBP with versatile functions in normal and cancer stem cells",
abstract = "Musashi1 (Msi1) is a highly conserved RNA binding protein that was initially identified in Drosophila by its ability to regulate sensory organ development and asymmetric cell division. Studies in mammalian cells reveal multiple functions for Musashi1 in normal and abnormal processes by mediating different posttranscriptional processes. According to our recent studies, Musashi1 very likely controls hundreds of targets, forming networks that regulate apoptosis, differentiation, proliferation and cell cycle. Musashi1 is a characteristic stem cell marker that regulates the balance between selfrenewal and differentiation. Over-expression of Musashi1 has been associated with numerous tumor types and its function is required for tumor growth in breast, colon, medulloblastoma and glioblastoma. Musashi1 has also been implicated in neurogenesis and neurodegenerative diseases, and is emerging as a potential therapeutic target in both regenerative medicine and cancer.",
keywords = "Cancer, Cancer Stem Cell, Musashi1, Nervous System Development, Neurological Disease, Post-Transcriptional Gene Regulation, Review, Ribonomics, RNA-Binding Protein, Splicing, Stem Cell, Translational Regulation",
author = "Glazer, {Robert I.} and Vo, {Dat T.} and Penalva, {Luiz O.F.}",
year = "2012",
month = "1",
day = "1",
doi = "10.2741/3915",
language = "English (US)",
volume = "17",
pages = "54--64",
journal = "Frontiers in Bioscience - Landmark",
issn = "1093-9946",
publisher = "Frontiers in Bioscience",
number = "1",

}

TY - JOUR

T1 - Musashi1

T2 - An RBP with versatile functions in normal and cancer stem cells

AU - Glazer, Robert I.

AU - Vo, Dat T.

AU - Penalva, Luiz O.F.

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Musashi1 (Msi1) is a highly conserved RNA binding protein that was initially identified in Drosophila by its ability to regulate sensory organ development and asymmetric cell division. Studies in mammalian cells reveal multiple functions for Musashi1 in normal and abnormal processes by mediating different posttranscriptional processes. According to our recent studies, Musashi1 very likely controls hundreds of targets, forming networks that regulate apoptosis, differentiation, proliferation and cell cycle. Musashi1 is a characteristic stem cell marker that regulates the balance between selfrenewal and differentiation. Over-expression of Musashi1 has been associated with numerous tumor types and its function is required for tumor growth in breast, colon, medulloblastoma and glioblastoma. Musashi1 has also been implicated in neurogenesis and neurodegenerative diseases, and is emerging as a potential therapeutic target in both regenerative medicine and cancer.

AB - Musashi1 (Msi1) is a highly conserved RNA binding protein that was initially identified in Drosophila by its ability to regulate sensory organ development and asymmetric cell division. Studies in mammalian cells reveal multiple functions for Musashi1 in normal and abnormal processes by mediating different posttranscriptional processes. According to our recent studies, Musashi1 very likely controls hundreds of targets, forming networks that regulate apoptosis, differentiation, proliferation and cell cycle. Musashi1 is a characteristic stem cell marker that regulates the balance between selfrenewal and differentiation. Over-expression of Musashi1 has been associated with numerous tumor types and its function is required for tumor growth in breast, colon, medulloblastoma and glioblastoma. Musashi1 has also been implicated in neurogenesis and neurodegenerative diseases, and is emerging as a potential therapeutic target in both regenerative medicine and cancer.

KW - Cancer

KW - Cancer Stem Cell

KW - Musashi1

KW - Nervous System Development

KW - Neurological Disease

KW - Post-Transcriptional Gene Regulation

KW - Review

KW - Ribonomics

KW - RNA-Binding Protein

KW - Splicing

KW - Stem Cell

KW - Translational Regulation

UR - http://www.scopus.com/inward/record.url?scp=84860330706&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84860330706&partnerID=8YFLogxK

U2 - 10.2741/3915

DO - 10.2741/3915

M3 - Article

C2 - 22201732

AN - SCOPUS:84860330706

VL - 17

SP - 54

EP - 64

JO - Frontiers in Bioscience - Landmark

JF - Frontiers in Bioscience - Landmark

SN - 1093-9946

IS - 1

ER -