Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

Paul Hasty, Allan Bradley, Julla H. Morris, Diane G. Edmondson, Judith M. Venuti, Eric N. Olson, William H. Klein

Research output: Contribution to journalArticle

909 Citations (Scopus)

Abstract

Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role in vivo, mice homozygous for a targeted mutation in the myogenin gene were generated. These mice survive fetal development but die immediately after birth and show a severe reduction of all skeletal muscle. Myogenin-mutant mice differ from mice carrying mutations in genes for the related myogenic factors Myf5 and MyoD, which have no muscle defects. Myogenin is therefore essential for the development of functional skeletal muscle.

Original languageEnglish (US)
Pages (from-to)501-506
Number of pages6
JournalNature
Volume364
Issue number6437
StatePublished - Aug 5 1993

Fingerprint

Myogenin
Muscles
Mutation
Genes
Skeletal Muscle
MyoD Protein
Muscle Development
Fetal Development
Transcription Factors
Perinatal Death
Parturition

ASJC Scopus subject areas

  • General

Cite this

Hasty, P., Bradley, A., Morris, J. H., Edmondson, D. G., Venuti, J. M., Olson, E. N., & Klein, W. H. (1993). Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature, 364(6437), 501-506.

Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. / Hasty, Paul; Bradley, Allan; Morris, Julla H.; Edmondson, Diane G.; Venuti, Judith M.; Olson, Eric N.; Klein, William H.

In: Nature, Vol. 364, No. 6437, 05.08.1993, p. 501-506.

Research output: Contribution to journalArticle

Hasty, P, Bradley, A, Morris, JH, Edmondson, DG, Venuti, JM, Olson, EN & Klein, WH 1993, 'Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene', Nature, vol. 364, no. 6437, pp. 501-506.
Hasty P, Bradley A, Morris JH, Edmondson DG, Venuti JM, Olson EN et al. Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature. 1993 Aug 5;364(6437):501-506.
Hasty, Paul ; Bradley, Allan ; Morris, Julla H. ; Edmondson, Diane G. ; Venuti, Judith M. ; Olson, Eric N. ; Klein, William H. / Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. In: Nature. 1993 ; Vol. 364, No. 6437. pp. 501-506.
@article{6ae3ec0f72ff4c9792ea23179099acc8,
title = "Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene",
abstract = "Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role in vivo, mice homozygous for a targeted mutation in the myogenin gene were generated. These mice survive fetal development but die immediately after birth and show a severe reduction of all skeletal muscle. Myogenin-mutant mice differ from mice carrying mutations in genes for the related myogenic factors Myf5 and MyoD, which have no muscle defects. Myogenin is therefore essential for the development of functional skeletal muscle.",
author = "Paul Hasty and Allan Bradley and Morris, {Julla H.} and Edmondson, {Diane G.} and Venuti, {Judith M.} and Olson, {Eric N.} and Klein, {William H.}",
year = "1993",
month = "8",
day = "5",
language = "English (US)",
volume = "364",
pages = "501--506",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "6437",

}

TY - JOUR

T1 - Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

AU - Hasty, Paul

AU - Bradley, Allan

AU - Morris, Julla H.

AU - Edmondson, Diane G.

AU - Venuti, Judith M.

AU - Olson, Eric N.

AU - Klein, William H.

PY - 1993/8/5

Y1 - 1993/8/5

N2 - Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role in vivo, mice homozygous for a targeted mutation in the myogenin gene were generated. These mice survive fetal development but die immediately after birth and show a severe reduction of all skeletal muscle. Myogenin-mutant mice differ from mice carrying mutations in genes for the related myogenic factors Myf5 and MyoD, which have no muscle defects. Myogenin is therefore essential for the development of functional skeletal muscle.

AB - Myogenin is a muscle-specific transcription factor that can induce myogenesis in a variety of cell types in tissue culture. To test myogenin's role in vivo, mice homozygous for a targeted mutation in the myogenin gene were generated. These mice survive fetal development but die immediately after birth and show a severe reduction of all skeletal muscle. Myogenin-mutant mice differ from mice carrying mutations in genes for the related myogenic factors Myf5 and MyoD, which have no muscle defects. Myogenin is therefore essential for the development of functional skeletal muscle.

UR - http://www.scopus.com/inward/record.url?scp=0027258162&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027258162&partnerID=8YFLogxK

M3 - Article

C2 - 8393145

AN - SCOPUS:0027258162

VL - 364

SP - 501

EP - 506

JO - Nature

JF - Nature

SN - 0028-0836

IS - 6437

ER -