Muscle development and differentiation

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Skeletal muscle is formed through the differentiation and fusion of myoblasts into a multinucleated syncytium. Advances in molecular biology techniques and the generation of transgenic mouse models have contributed to the identification of the molecular pathways involved in skeletal muscle growth and differentiation. During embryogenesis, the specification and development of the myogenic lineage is determined by the spatiotemporal expression of a family of muscle-specific transcription factors. Understanding the molecular mechanism controlling skeletal muscle development may lead to new insights into therapeutic strategies that may alleviate some of the pathological conditions associated with muscular diseases.

Original languageEnglish (US)
Title of host publicationPrinciples of Molecular Medicine
PublisherHumana Press
Pages665-673
Number of pages9
ISBN (Print)9781588292025
DOIs
StatePublished - Dec 1 2006

Keywords

  • MEF2 proteins
  • MRF4
  • Myf5
  • MyoD
  • bHLH proteins
  • growth factors
  • myoblast
  • myogenesis
  • myogenin
  • skeletal muscle
  • somites

ASJC Scopus subject areas

  • Medicine(all)

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