Muscle is the major source of plasma gelsolin

D. J. Kwiatkowski, R. Mehl, S. Izumo, B. Nadal-Ginard, H. L. Yin

Research output: Contribution to journalArticle

128 Scopus citations

Abstract

Gelsolin, a Ca2+- and polyphosphoinositide-regulated actin-binding protein, is unique among vertebrate proteins in being both cytoplasmic and secreted. Plasma gelsolin, present at > 200 μg/ml in human plasma, may have a protective function by promoting the clearance of actin filaments released during tissue injury. Although there is evidence that smooth muscle tissues and HepG2 cells synthesize plasma gelsolin, the predominant secretory source is hitherto unknown. We report here that skeletal, cardiac, and smooth muscles have large amounts of plasma gelsolin mRNA and devote 0.5-3% of their biosynthetic activity to plasma gelsolin, whereas liver makes relatively little. Since skeletal muscle accounts for a large fraction of body mass and total protein synthesis, it is the major source of plasma gelsolin.

Original languageEnglish (US)
Pages (from-to)8239-8243
Number of pages5
JournalJournal of Biological Chemistry
Volume263
Issue number17
StatePublished - 1988

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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    Kwiatkowski, D. J., Mehl, R., Izumo, S., Nadal-Ginard, B., & Yin, H. L. (1988). Muscle is the major source of plasma gelsolin. Journal of Biological Chemistry, 263(17), 8239-8243.