A patient with muscle phosphoglycerate mutase deficiency (PGAMD) and exercise-induced muscle cramps had tubular aggregates in muscle and increased muscle Ca2+-adenosine triphosphatase and calcium content. Two ischemic forearm exercise tests induced contractures in the patient. On dantrolene treatment, the patient became asymptomatic, and the ischemic test was performed without contracture. These findings suggest that cramps in muscle PGAMD are caused by a high calcium release from the sarcoplasmic reticulum relative to calcium reuptake capacity.
|Original language||English (US)|
|Number of pages||4|
|Journal||Annals of Neurology|
|State||Published - Aug 23 1999|
ASJC Scopus subject areas
- Clinical Neurology