Mutant mice and neuroscience: Recommendations concerning genetic background

Alcino J. Silva, Elizabeth M. Simpson, Joseph S. Takahashi, Hans Peter Lipp, Shigetada Nakanishi, Jeanne M. Wehner, Karl P. Giese, Tim Tully, Ted Abel, Paul F. Chapman, Kevin Fox, Seth Grant, Shigeyoshi Itohara, Richard Lathe, Mark Mayford, James O. McNamara, Roger J. Morris, Marina Picciotto, John Roder, Hee Sup ShinPaul A. Slesinger, Daniel R. Storm, Michael P. Stryker, Susumu Tonegawa, Yanyan Wang, David P. Wolfer

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Abstract

Controlling genetic background during the construction and testing of mutants is complex. Here, we propose that the genetic background of the mutants should always be described in detail, and that any background used should be easily recreated from available stocks. We also propose that both transgenic and gene-targeted mice be generated and maintained in inbred genetic backgrounds (i.e., either 129/J and/or C57BL/6). We propose the study of F1 hybride mice whenever possible (50% C57BL/6 and 50% 129/J). It is important to standardize the genetic background of the mutants studied the facilitate the comparison of results between experiments and among laboratories.

Original languageEnglish (US)
Pages (from-to)755-759
Number of pages5
JournalNeuron
Volume19
Issue number4
DOIs
Publication statusPublished - Oct 1997

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ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Silva, A. J., Simpson, E. M., Takahashi, J. S., Lipp, H. P., Nakanishi, S., Wehner, J. M., ... Wolfer, D. P. (1997). Mutant mice and neuroscience: Recommendations concerning genetic background. Neuron, 19(4), 755-759. https://doi.org/10.1016/S0896-6273(00)80958-7