Mutant mice and neuroscience: Recommendations concerning genetic background

Alcino J. Silva, Elizabeth M. Simpson, Joseph S. Takahashi, Hans Peter Lipp, Shigetada Nakanishi, Jeanne M. Wehner, Karl P. Giese, Tim Tully, Ted Abel, Paul F. Chapman, Kevin Fox, Seth Grant, Shigeyoshi Itohara, Richard Lathe, Mark Mayford, James O. McNamara, Roger J. Morris, Marina Picciotto, John Roder, Hee Sup ShinPaul A. Slesinger, Daniel R. Storm, Michael P. Stryker, Susumu Tonegawa, Yanyan Wang, David P. Wolfer

Research output: Contribution to journalComment/debate

352 Scopus citations

Abstract

Controlling genetic background during the construction and testing of mutants is complex. Here, we propose that the genetic background of the mutants should always be described in detail, and that any background used should be easily recreated from available stocks. We also propose that both transgenic and gene-targeted mice be generated and maintained in inbred genetic backgrounds (i.e., either 129/J and/or C57BL/6). We propose the study of F1 hybride mice whenever possible (50% C57BL/6 and 50% 129/J). It is important to standardize the genetic background of the mutants studied the facilitate the comparison of results between experiments and among laboratories.

Original languageEnglish (US)
Pages (from-to)755-759
Number of pages5
JournalNeuron
Volume19
Issue number4
DOIs
StatePublished - Oct 1997

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Mutant mice and neuroscience: Recommendations concerning genetic background'. Together they form a unique fingerprint.

  • Cite this

    Silva, A. J., Simpson, E. M., Takahashi, J. S., Lipp, H. P., Nakanishi, S., Wehner, J. M., Giese, K. P., Tully, T., Abel, T., Chapman, P. F., Fox, K., Grant, S., Itohara, S., Lathe, R., Mayford, M., McNamara, J. O., Morris, R. J., Picciotto, M., Roder, J., ... Wolfer, D. P. (1997). Mutant mice and neuroscience: Recommendations concerning genetic background. Neuron, 19(4), 755-759. https://doi.org/10.1016/S0896-6273(00)80958-7