Mutation of the conserved N-terminal cysteine (Cys92) of human presenilin 1 causes increased Aβ₄₂ secretion in mammalian cells but impaired Notch/lin-12 signalling in C. elegans

Medicine & Life Sciences

• human PSEN1 protein 100%
• Presenilins 78%
• Cysteine 51%
• Amyloid beta-Protein Precursor 31%
• Mutation 30%
• Amyloid Precursor Protein Secretases 16%
• Loss of Function Mutation 15%
• Missense Mutation 14%
• Proteins 10%