TY - JOUR
T1 - Mutation of the mouse klotho gene leads to a syndrome resembling ageing
AU - Kuro-o, Makoto
AU - Matsumura, Yutaka
AU - Aizawa, Hiroki
AU - Kawaguchi, Hiroshi
AU - Suga, Tatsuo
AU - Utsugi, Toshihiro
AU - Ohyama, Yoshio
AU - Kurabayashi, Masahiko
AU - Kaname, Tadashi
AU - Kume, Eisuke
AU - Iwasaki, Hitoshi
AU - Iida, Akihiro
AU - Shiraki-Iida, Takako
AU - Nishikawa, Satoshi
AU - Nagai, Ryozo
AU - Nabeshima, Yo Ichi
PY - 1997/11/6
Y1 - 1997/11/6
N2 - A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the β-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
AB - A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the β-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
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U2 - 10.1038/36285
DO - 10.1038/36285
M3 - Article
C2 - 9363890
AN - SCOPUS:0030724491
SN - 0028-0836
VL - 390
SP - 45
EP - 51
JO - Nature
JF - Nature
IS - 6655
ER -