Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro-o, Yutaka Matsumura, Hiroki Aizawa, Hiroshi Kawaguchi, Tatsuo Suga, Toshihiro Utsugi, Yoshio Ohyama, Masahiko Kurabayashi, Tadashi Kaname, Eisuke Kume, Hitoshi Iwasaki, Akihiro Iida, Takako Shiraki-Iida, Satoshi Nishikawa, Ryozo Nagai, Yo Ichi Nabeshima

Research output: Contribution to journalArticlepeer-review

2430 Scopus citations

Abstract

A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the β-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.

Original languageEnglish (US)
Pages (from-to)45-51
Number of pages7
JournalNature
Volume390
Issue number6655
DOIs
StatePublished - Nov 6 1997

ASJC Scopus subject areas

  • General

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